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Likewise, 26RFa administration also significantly decreased (P less than 0.
Keywords: Hypothalamus-pituitary-gonadal axis, kisspeptin-10, 26RFa, plasma testosterone, chicken.
The genes encoding 26RFa and GPR103 are expressed in various brain areas including hypothalamus (Chartrel et al.
2008), but currently, to thebest of our knowledge, no data are available for the role of KP and 26RFa in the avian reproductive physiology.
Human 26RFa (TSGPLGNLAEELNGYSRKKGGFSFRF- NH2) was synthesized in the lab of one of the authors (Dr.
The experimental design of this study consisted of blood samplings before and after KP10, 26RFa, vehicle (normal saline), and hCG intravenous (i.
A single dose of 26RFa (38-nmol) was administered to a group of four birds.
The doses of KP10 and 26RFa were selected from the neuroendocrine effective doses of these peptides in monkeys.
Recently, two new members of the RFamide superfamily of peptides, KP and 26RFa have been identified (Chartrel et al.
In the present study, therefore, we have studied the effect of peripheral administration of human KP10 and human 26RFa on the plasma T levels in the adult male broiler breeder birds.
The mechanisms of the inhibitory action of 26RFa on plasma T secretion are not clear but it shares Arg-Phe-NH2 sequence at the C-terminus with other RFamide peptides (Chartrel et al.
The site of action of inhibitory effect of KP10 and 26RFa on the T release in chickens is unknown.
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