(redirected from 20-methylcholanthrene)


A highly carcinogenic hydrocarbon that can be formed chemically from deoxycholic or cholic acids, or from cholesterol; it induces the synthesis of cytochrome P-450 mRNA; the choice between 3- or 20- for the methyl group depends upon whether hydrocarbon (inner) or steroid (outer) numbering is chosen; in the latter case, the formal relationship to the cholic acids and cholesterol is clear.
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References in periodicals archive ?
They also found that intraperitoneal injections of NSE significantly reduced the incidence of sarcoma development after 30 days of subcutaneous 20-methylcholanthrene (MCA) injections.
In animal trials, anthroposophically processed Viscum album extracts exerted protective effects against carcinogenic compounds (N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide, 20-methylcholanthrene) in trials with rats and mice [36, 37].
The in vivo and in vitro inhibitory effects of TQ against 20-methylcholanthrene (MC)-induced fibrosarcoma (Badary and Gamal, 2001) and against benzo[a]pyrene-induced forestomach carcinogenesis (Badary et al., 1999) were reported in mice.
Development of hepatomas in inbred albino mice following treatment with 20-methylcholanthrene. Cancer Res 19:1109-1113.
On the factor of age in the production of subcutaneous sarcomas in mice by 20-methylcholanthrene. J Natl Cancer Inst 14:547-569 (1954).