1) were synthesized by reacting acetophenone with 2-aminobenzoic acid 4- aminobenzoic acid 2-naphthylamine
phenylhydrazine 12-ethanediamine 12- diaminobenzene and 14-diaminobenzene res pectively and characterized as reported earlier .
, and 4-aminobiphenyl are possible carcinogenic agents found in cigarette smoke3.
The first such association was observed in 1895 (Rehn 1895), and subsequent research among dyestuff workers identified the aromatic amines benzidine and 2-naphthylamine
as bladder carcinogens (Case et al.
The chemicals include benzene and 2-naphthylamine
, known human carcinogens, cadmium and n-nitrosodiethanolamine, which is associated with cancer in humans, and polonium-210, an element that emits alpha radiation.
Additionally, some of the known carcinogens, such as benzo(a)pyrene, benzene, 2-naphthylamine
, and dimethylnitrosamine, are found in higher concentrations in sidestream smoke.
After N-oxidation of aromatic amines such as 4-aminobiphenyl or 2-naphthylamine
by CYP1A2 in the liver, O-acetylation of the resulting hydroxylamine by NAT2 can produce unstable acetoxy esters that decompose to form highly electrophilic aryl nitrenium ion species.