cysteamine

(redirected from 2-mercaptoethylamine)
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cysteamine

 [sis-te´ah-mēn″]
a sulfhydryl amine that is part of coenzyme A; it reduces intracellular cystine levels and is used in treatment of nephropathic cystinosis; administered orally.

cys·te·a·mine

(sis-tā'a-mēn),
2-Aminoethanethiol; a sulfhydryl compound used experimentally to produce ulcers in rats and as a radioprotective agent; antidote to acetaminophen.

cysteamine

A stable aminothiol and metabolite of the amino acid cysteine.

Physiologic role
Cysteamine forms coenzyme A by combining with pantothenate and adenosine triphosphate.

Potential therapeutic role
Cysteamine has been in clinical trials for managing Batten disease, cystinosis, non-alcoholic steatohepatitis and Huntington's disease.

cysteamine

Mercaptamine, a drug used to treat NEPHROPATHIC CYSTINOSIS and prescribable only by urological specialists. A brand name is Cystagon.
References in periodicals archive ?
After the addition of 10 [micro]L of the internal standard (IS; 2-mercaptoethylamine) to 200 [micro]L plasma, the mixture of disulfides, mixed disulfides, and protein-bound thiols is reduced using 20 [micro]L of tris(2-carboxyethyl)phosphine (TCEP).
The [F(ab').sub.2[micro]] of 9CA10 was reduced to [Fab'.sub.[micro]], SH with 50 mmol/L 2-mercaptoethylamine (Sigma) in phosphate-buffered saline (PBS) containing 10 mmol/L EDTA at 37'C for 1 h, and was separated from 2-mercaptoethylamine by size exclusion HPLC on a TSKgel [G3000SW.sub.XL] column.
Fab' was then prepared by reduction with 10 mmol/L 2-mercaptoethylamine in 0.1 mol/L sodium phosphate buffer, pH 6.0, containing 5 mmol/L EDTA, followed by purification on a Sephadex G-25 column (1 X 47 cm, Amersham Pharmacia Biotech) in the same buffer.

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