2-deoxy-d-glucose

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2-deoxy-d-glucose

 [de-ok´sĭ-gloo´kōs]
an antimetabolite of glucose with antiviral activity; it acts by inhibiting the glycosylation of glycoproteins and glycolipids; it has been investigated for treatment of herpesvirus infections.
References in periodicals archive ?
While they found that the antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with vitamin C outperforming 2-DG by tenfold in terms of potency.
One of the selection strategies in mutagenesis is the use of simple sugar like glucose and non-metabolizable analogs like 2-deoxyglucose (2-DG), it increases the enzyme activity and provides feedback resistance [15].
Conidia were isolated from the sporulation medium and grown in liquid minimal medium with 0.5% (w/v) xylan plus 0.5 % (w/v) 2-DG.
While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with vitamin C outperforming 2-DG by tenfold in terms of potency.
A total of 234 samples from SUP-15, SD1, and REH leukemia cell lines were treated with vehicle (Benzyl alcohol, AB), MP, and 2-DG or the combination for 0, 6, 12, 18, 24, and 48 h.
For each noncontrol condition--that is, any treatment with MP, 2-DG, or 2-DG+MP--log-fold change values were calculated by subtracting the log-transformed intensities from the corresponding, that is, same cell line and time point, control sample.
The strongest increase in ONL cell death was observed after treatment with the glycolysis inhibitor 2-DG (Fig.
In the ONL, only the 2-DG treatment caused a significant reduction of nuclear rows (Fig.
After first determining that in vitro cancer cells incubated with 2-DG and exposed to low concentrations of ABT-263/737 died, the researchers conducted animal studies.
Role of T regulatory cells (CD[4.sup.+]CD[25.sup.+]FoxP[3.sup.+]) and Th1, Th2 and Th3 cytokines in the radiosensization of Ehrlich ascites tumor by the glycolytic inhibitor 2-deoxy-D-glucose (2-DG).
We investigated whether 2-DG reduced insulin synthesis which had been increased by melatonin via autophagy in rat insulinoma INS-1E cells.
Chlorogenic acid, ferulic acid and berberine cause a modest, but significant, increase in 2-DG transport into the L6 myotubes and their performance is comparable to both the commercial oral hypoglycemic drugs.