Dosedependent effects of sertoli cell toxicants 2,5-hexanedione
, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis.
and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules.
Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione
At CDC's National Institute for Occupational Safety and Health (NIOSH), recent exposure to n-hexane was estimat ed by measuring 2,5-hexanedione (2,5-HD), a urinary metabolite, in acid-hydrolyzed urine samples.
Potentiation of 2,5-hexanedione neurotoxicity by methyl ethyl ketone.
and carbendazim coexposure synerg istically disrupts rat spermatogenesis despite opposing molecular effects on microtubules.
Stem cell kinetics in rat testis after irreversible injury induced by 2,5-hexanedione
exposure in the rat results in long-term testicular atrophy despite the presence of residual spermatogonia.
n-Hexane is hydroxylated at the 2 and 5 positions primarily by cytochrome P450 (CYP) 2E1, leading to formation of the neurotoxic metabolite, 2,5-hexanedione
(Zhang et al.
5 hr Phenol Urine 5 hr Carbon monoxide Carboxyhemoglobin Blood Short 5 hr Styrene Mandelic acid Urine 14 hr n-Hexane 2,5-Hexanedione
Urine 18 hr Polycyclic Pyrenol Urine hydrocarbons 96 hr Perchloroethylene Perchloroethylene Blood and exhaled air Long 18 days Mercury Mercury Blood and urine 30 days Lead Lead Blood 100 days Cadmium Cadmium Blood Very long 2 years Hexachlorobenzene Hexachlorobenzene Serum 5 years Lead Lead Bones 7 years 2,3,7,8-TCDD 2,3,7,8-TCDD Blood > 10 years Cadmium Cadmium Urine 2,3,7,8-TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Other investigators have shown similar effects with 2,5-hexanedione (31).
Sertoli cell microtubules have previously been proposed as a target of 2,5-hexanedione (32,33).