In neonates clinical and haematological picture is more severe due to increase level of Hb F as it increases the level of 2,3-DPG
which destabilizes spectrin-actin interaction thus exacerbating the defect.
The depletion of 2,3-DPG
lead to the left-shift of oxygen dissociation curve, and therefore, reduce oxygen delivery.
1990) have reported higher P50 values (oxygen tension at 50% oxygen saturation) and increased 2,3-DPG
concentrations in females, which may result in females being less responsive to SP supplementation compared with males (Fukuda et al.
At altitude, increased levels of red blood cell 2,3-DPG
promote oxygen unloading at the muscle tissue level and, theoretically, an increase in oxygen utilization.
With a reduction in red blood cell 2,3-DPG
, the affinity of the red cells for oxygen increases, the cells being less able to release oxygen to the tissues.
Fetal hyperglycemia, fetal hyperinsulinemia, as well as decreased 2,3-DPG
levels causing an increased affinity of maternal hemoglobin for oxygen can lead to lactic acidosis and hypoxia in the fetus (2),(5).
But stored blood loses a chemical called 2,3-DPG
(for 2,3 diphosphoglycerate) that facilitates the unloading of oxygen from hemoglobin molecules on red blood cells.
is produced in the red cell in the pentose phosphate pathway as a result of glucose being metabolized to lactate.
funciona como un efector alosterico para la Hb.
These findings suggest that the absence of proline [beta]5 slightly affects the spatial positions of Val at NA1 and His at NA2 and indirectly affects the off-loading of 2,3-DPG
as observed in Hb Warwickshire.
Inside a living red cell, molecules called 2,3-DPG
float around and serve to "adjust" hemoglobin's affinity for oxygen that passes through the cell membrane.
Some research support this hypothesis, while other studies do not show significant changes in the level of erythrocyte 2,3-DPG
following sodium phosphate supplementation (Bredle et al.