dioxin

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dioxin

 [di-ok´sin]
a highly toxic and teratogenic chlorinated hydrocarbon that is a trace contaminant in the herbicides2,4,5-T and agent orange.

di·ox·in

(dī-oks'in),
1. A ring consisting of two oxygen atoms, four CH groups, and two double bonds; the positions of the oxygen atoms are specified by prefixes, as in 1,4-dioxin.
2. Abbreviation for dibenzo[b,e][1,4]dioxin which may be visualized as an anhydride of two molecules of 1,2-benzenediol (pyrocatechol), thus forming two oxygen bridges between two benzene moieties, or as a 1,4-dioxin with a benzene ring fused to catch each of the two CH=CH groups.
3. A contaminant in the herbicide, 2,4,5-T; it is potentially toxic, teratogenic, and carcinogenic.

dioxin

/di·ox·in/ (-ok´sin) any of the heterocyclic hydrocarbons present as trace contaminants in herbicides; many are oncogenic and teratogenic.

dioxin

(dī-ŏk′sĭn)
n.
Any of several carcinogenic, mutagenic, and teratogenic polychlorinated heterocyclic aromatic hydrocarbons that can occur as impurities in petroleum-derived herbicides and as byproducts of manufacturing chemicals and burning fuels and waste.

dioxin

[dī·ok′sin]
a contaminant of the herbicide 2,4,5-trichlorophenoxyacetic acid, widely used throughout the world in forestry, on grassland, against woody shrubs and trees on industrial sites, and for rice and sugarcane weed control. Because of its toxicity it is no longer manufactured in the United States. Exposure to dioxin is associated with chloracne and porphyria cutanea tarda. Dioxin was a contaminant of the jungle defoliant Agent Orange sprayed by the U.S. military aircraft over areas of Southeast Asia from 1965 to 1970. Also called 2,3,7,8-tetrachlorodibenzo-para-dioxin.
Any of a family of highly toxic chlorinated hydrocarbons in which 2 benzene rings are linked by 2 O2 atoms, which includes dibenzodioxins and dibenzofurans
Lab Increased PT, increased lipid levels

dioxin

Toxicology Any of a family of highly toxic chlorinated hydrocarbons Clinical In humans, intense chronic exposure causes weight loss, myalgias, insomnia, dyspnea, cold intolerance, irritability, peripheral neuropathy, hepatomegaly, hemorrhagic cystitis, chloracne, actinic elastosis, loss of libido, impotence Lab ↑ PT, ↑ lipid levels. See Agent Orange, Times Beach.

di·ox·in

(dī-ok'sin, dī-ok'sin)
1. A ring consisting of two oxygen atoms, four CH groups, and two double bonds; the positions of the oxygen atoms are specified by prefixes, as in 1,4-dioxin.
2. A contaminant in the herbicide, 2,4,5-T; its potential toxicity, carcinogenicity, and teratogenicity are controversial.

dioxin

a chemical byproduct of the manufacture of certain herbicides and bactericides, particularly tetrachlorodibenzo-paradioxin (TCDD), which is extremely toxic.

Dioxin

A toxic chemical found in weed killers that has been linked to the development of endometriosis.
Mentioned in: Endometriosis

dioxin

a highly toxic and teratogenic chlorinated hydrocarbon that is a trace contaminant in the herbicide 2,4,5-T. Acute poisoning causes vomiting, abortion, anestrus. Chronic poisoning causes liver damage, especially in dogs. Congenital defects caused include cranio-facial deformity and anasarca. It is excreted in the milk.
References in periodicals archive ?
Retinoic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin selectively enhance teratogenesis in C57BL/6N mice.
Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect.
Gestational exposure to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induces BRCA-1 promoter hypermethylation and reduces BRCA-1 expression in mammary tissue of rat offspring: preventive effects of resveratrol.
2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture.
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver.
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis in neural growth factor (NGF)-differentiated pheochromocytoma PC12 cells.
Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
The estimation of elimination rates of persistent compounds: a reanalysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans.
Comparative acute lethality of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in the most TCDD-susceptible and the most TCDD-resistant rat strain.
In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring.
METHODS: Using human multipotent adipose-derived stem cells, we carried out large-scale gene expression analysis to identify the major pathways modified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyl (PCB) congener 126 (PCB-126), and PCB-153 and to evaluate their toxic effects.

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