S100A4

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S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
References in periodicals archive ?
S100A4, which is a multifunctional [Ca.sup.2+] signaling protein found in the cytoplasm and extracellular space, is also called metastasin (Mts1), pEL-98, 18A2, 42A, p9Ka, CAPL, calvasculin, and fibroblast-specific protein (FSP1) [11,12,16].
Anti-CD44 (clone IM7 mIgG2b) was from eBioscience, anti-CD56 (clone AF12-7H3 mIgG1) was from Myltenyi Biotec, and anti-CD140b (clone 18A2 mIgG1) was from BioLegend.
Centrin 1 (Cetn1) is a retroposon-derived gene, located on chromosome 18A2, that encodes a protein component of the centrosome.