YWHAE

(redirected from 14-3-3 protein epsilon)

YWHAE

A gene on chromosome 17p13.3 that encodes an adapter protein which regulates a broad spectrum of general and specialised signalling pathways by binding to a large number of partners, usually by recognising a phosphoserine or phosphothreonine motif.
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Proteins exclusively expressed in the MSC senescent phenotypes Name of protein UniProt ID Extracellular Filamin B E7EN95 matrix/cytoskeleton/cell Tubulin alpha 1C chain F5H5D3 junctions Tubulin beta chain Q5JP53 Ox-redox factors Peroxiredoxin 6 P30041 Protein deglycase Q99497 DJ-1(PARK7) I3L3M7 TXNDC5 (ERP46) Regulators of gene Major vault protein Q14764 expression 14-3-3 protein epsilon P62258 Proteasome subunit P28070 beta type 4 Miscellaneous Aminopeptidase N (CD13) P15144 Cathepsin D P07339 Venn analysis allowed the identification of 11 proteins that were shared and exclusively expressed in all the different senescent phenotypes and absent in the secretomes of healthy mesenchymal stromal cells (MSCs).