Protein 14-3-3 (Centre for Research in Neurodegenerative Disease at the University of Toronto) was present in the CSF.
Recent efforts to improve diagnostic accuracy for CJD have focused on measuring CSF protein 14-3-3. Thought to reflect neuronal injury, reported sensitivities and specificities of CSF protein 14-3-3 for CJD in patients with rapidly progressive dementia are 84%-96% and 87%-100%, respectively (15-21).
CSF protein 14-3-3 does not entirely rule out potentially treatable causes, and in this case an angiogram would likely not have been able to differentiate inflammatory from infectious vasculitis.
The 14-3-3 brain protein in cerebrospinal fluid as a marker far transmissible spongiform encephalopathies.
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
14-3-3 testing in diagnosing Creutzfeldt-Jakob disease.
(20.) Burkhard PR, Sanchez J-C, Landis T, Hochstrasser DE CSF detection of the 14-3-3 protein in unselected patients with dementia.