13-cis-retinoic acid

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13-cis-ret·i·no·ic ac·id

the retinoid most used in the U.S. to treat acne; it works by reducing sebum secretion. Use in pregnancy is contraindicated because of teratogenicity.
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References in periodicals archive ?
Beta carotene and 13-cis-retinoic acid both belong to a family of compounds known as the retinoids.
The new study represents the first long-term comparison of 13-cis-retinoic acid and beta carotene.
The patents describe methods of using 13-Cis-Retinoic Acid to treat three different medical conditions: 1) benign prostatic hyperplasia and other benign prostate conditions; 2) plantar and palmar fibrosis (Dupuytren's contracture); and 3) musculoskeletal and connective tissue inflammations including osteoarthritis and associated articular and periarticular inflammations, and non-articular Rheumatism.
Conclusion: The 13-cis-retinoic acid has no significant inhibitory effect on uterine glandular proliferation induced by tamoxifen after a short-term administration of three months.
It has been observed in animal studies that 13-cis-retinoic acid (13cRA) inhibits the process of epithelial carcinogenesis and also prevents the progression of chemically-induced benign into malignant tumours.
The adjuvant administration of 13-cis-retinoic acid produced a statistically significant (p = 0.
13-cis-retinoic acid is a retinoid which has been found to be effective in preventing epithelial carcinogenesis in animal studies on rats and also preventing the malignant conversion of chemically induced benign tumors.
Dr Veal and colleagues studied 70 patients receiving 13-cis-retinoic acid from hospitals around the UK and found that particularly in babies, where doses prescribed are often lower than those received by older children, levels of 13-cis-retinoic acid in the blood were frequently much lower than those thought to be effective.
The study has led to changes in the way that this important drug is dosed in the majority of neuroblastoma patients, with babies now given the same dose as older children and patients who are not able to swallow the 13-cis-retinoic acid capsules also prescribed an increased dose level.
This chapter is dense and goes into detail on the interactions of retinoids with the cell signalling pathways, the actions on growth factors and cytokines (including interferons whose successful action in the chemoprevention of head and neck carcinoma along with 13-cis-retinoic acid has been investigated).
Amanda Nelson, also from the Penn State group looked further into the question of how 13-cis-retinoic acid (13-cis-RA) causes sebaceous gland atrophy.