isotretinoin

(redirected from 13-cis retinoic acid)
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isotretinoin

 [i″so-tret´ĭ-no-in]
a synthetic form of retinoic acid (13-cis-retinoic acid), used orally to clear cystic and conglobate acne.

i·so·tret·i·noin

(ī'sō-tret'i-noyn),
A retinoid used to treat severe recalcitrant cystic acne; a known human teratogen.

isotretinoin

(ī′sō-trĕt′n-oin′)
n.
A synthetic isomer of retinoic acid that inhibits sebaceous gland secretion and is used in the treatment of severe nodular acne. It can cause birth defects if taken during pregnancy.

isotretinoin

Retinoic acid, 13-cis retinoic acid A retinoid used to treat acne and psoriasis and may ↓ tumor development Side effects Inflammation of skin and mucosa, hepatitis

i·so·tret·i·no·in

(ī'sō-tret'i-nō'in)
A retinoid used to treat severe recalcitrant cystic acne; a known human teratogen.

isotretinoin

A RETINOID drug used to treat ACNE. The oral preparation is used under strictly controlled conditions to exclude pregnancy because of the known risks to the fetus. Brand names are Roaccutane, and, for external use Isotrex and Isotrexin.

Isotretinoin

A powerful vitamin A derivative used in the treatment of acne. It can promote scarring after skin resurfacing procedures.
Mentioned in: Acne, Skin Resurfacing

i·so·tret·i·no·in

(ī'sō-tret'i-nō'in)
A retinoid used to treat severe recalcitrant cystic acne; known human teratogen.
References in periodicals archive ?
Interventions were chemopreventive agents such as vitamin A, isotretinoin (13-cis retinoic acid), beta-carotene, COX-2, bowman-brick inhibitor concentration, erlotinib, green tea extract, BRBs and ZengShengPing, a mixture of medicinal herbs.
Randomized trial of 13-cis retinoic acid compared with retinylpalmitate with or without beta-carotene in oral premalignancy.
13-cis retinoic acid significantly reduced the proliferative effect of tamoxifen on the area of the endometrium only.
The combination of 13-cis retinoic acid and interferon a-2a with radiation therapy in squamous cell carcinoma of the cervix.
13-cis retinoic acid (Ro acutance) a miracle drug in nodulocystic acne.
The effects of marked inhibition of sebum production with 13-cis retinoic acid on skin surface lipid composition.
Chemoprevention with interferon alfa and 13-cis retinoic acid in the adjunctive treatment of head and neck cancer.
"We don't feel the evidence is clear enough yet to recommend that people take 13-cis retinoic acid," Greenwald says.
13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes.
Both excess and deficiency of vitamin A can cause human embryo toxicity and congenital anomalies.19 In infants children and adults treated with either valproic acid monotherapy or with valproic acid in combination therapy significant alteration in the retinoid metabolism was noted.20 Another mechanism of embryo toxicity and teratogenicity might be high serum concentration of all-trans and 13-cis retinoic acid.