12-O-tetradecanoylphorbol 13-acetate
12-O-tet·ra·dec·a·no·yl·phor·bol 13-ac·e·tate
(tet'ră-dek'ă-nō-il-fōr'bol as'ĕ-tāt),A double ester of phorbol found in croton oil; a cocarcinogen or tumor promoter.
References in periodicals archive
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In this 2002 study the mouse skin tumor model, sesamol was found to provide a 50% reduction in skin papillomas at 20 weeks after promotion with 12-O-tetradecanoylphorbol 13-acetate. The researchers concluded that all of the dietary constituents appeared to provide chemopreventive effects.
Its use in in vivo anticancer studies performed on tumor production induced by 12-O-tetradecanoylphorbol 13-acetate and initiated by benzo(a) pyrene in mouse epidermis resulted in the normalization of skin cancers.
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