ALOX12

(redirected from 12-LOX)

ALOX12

A gene on chromosome 17p13.1 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.
References in periodicals archive ?
Like 5-LOX, inhibition of 12-LOX also reduced the numbers of living HCC cells by increasing apoptosis and reducing proliferation (Xu et al.
This was due, in part, to increased expression of 12-LOX and a related fatty acid called 12-HETE.
Cohen added that the data suggested that dietary sugar induces 12-LOX signaling to increase risks for breast cancer development and metastasis.
This was due, in part, to increased expression of 12-LOX [which plays a role in cell death] and a related fatty acid called 12-HETE.
In humans, the term 12/15-LOX refers to leukocyte-type 12-LOX and-reticulocyte-type 15-LOX-1 since they produce the similar lipid mediators such as 12-and 15-hydroperoxyeicosatetraenoic acids (HPETEs) and hydroxyeicosatetraenoic acids (HETEs).
To establish a connection between 12/15LOX and ceramide pathways in the brain we used the mice treated with baicalein, an inhibitor of human platelet 12-LOX and 15-LOX-1 [19].
Therefore, knipholone showed higher affinity for the 5-LOX pathway than for cycloxygenases and 12-LOX.
These effects were diminished by PLA2 inhibitor (quinacrine), general LOX inhibitors (NDGA, ETYA), 5-LOX inhibitors (Rev 5901, AA861), 12-LOX inhibitor (baicalein) and FLAP inhibitor (MK886), while COX inhibitor (indomethacin) was without effect.
The involvement of 12-LOX in malignant growth is suggested by overexpression in cancer cells and tissues and growth stimulation of malignant cell lines by 12-HETE (Natarajan and Nadler, 1998; Pidgeon et al.
To the best of our knowledge, this is the first report of lichen compounds being investigated for 12-LOX inhibitory properties.
In this study, we investigated the potential of 12-LOX as a predictor for the aggressiveness of prostate cancer.
Based on the literature survey, their various pharmacological activities, such as antioxidation, inhibition of COX-1, COX-2, 5-LOX, 12-LOX, suppression of iNOS, cytosolic protein kinase C, and inhibition of platelet aggregation, are summarized in Table 1.