11-deoxycorticosterone | definition of 11-deoxycorticosterone by Medical dictionary
deoxycorticosterone (redirected from 11-deoxycorticosterone)
Also found in: Dictionary
de·ox·y·cor·ti·cos·ter·one (DOC), (dē-oks'ē-kōr'ti-kos'tĕr-ōn),
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone, which occasionally appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
A steroid hormone, C21H30O3, secreted by the adrenal cortex or produced synthetically and formerly used to treat adrenal insufficiency.
deoxycorticosterone Endocrinology An adrenal steroid with potent mineralocorticoid properties, and minimal glucocorticosteroid properties ↑ in Congenital adrenal hyperplasia, Cushing syndrome, primary aldosteronism, low renin HTN, adrenal CA ↓ in Adrenal insufficiency or hypoplasia
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone and possibly aldosterone, which rarely appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Potent mineralocorticoid with no appreciable glucocorticoid activity.
11-desoxycorticosterone, deoxycorticosterone, deoxycortone
one of the mineralocorticoids, adrenocortical steroids which lack a substituent at C-11; has a greater effect on electrolyte metabolism than glucocorticoids. Available pharmaceutically as the acetate (DOCA), which is short-acting, and the pivalate (DOCP), a slow release form for use in the treatment of hypoadrenocorticism.
References in periodicals archive
We could detect no secretion of 11-deoxycorticosterone from these slices.
In slices exposed to tetracosactide, accumulation of corticosterone and 11-deoxycorticosterone in the medium increased linearly for about 48 hr.
11-Deoxycorticosterone secretion from slices exposed to both tetracosactide and metyrapone showed a 6-fold increase (p [is less than] 0.
8%) but worst with methylprednisolone (50%), 11-deoxycortisol (S) (16%), 11-deoxycorticosterone
(DOC) (27%), and triamcinolone (13%).
- 1,25-dihydroxyvitamin D
- 1,25-dihydroxyvitamin D3
- 1,4 butanediol
- 1,4-alpha-d-glucan 6-alpha-d-glucosyltransferase
- 1,4-alpha-d-glucan-branching enzyme
- 1,4-alpha-glucan branching enzyme
- 1,5 anhydroglucitol
- 100% displaced fracture
- 11-beta-hydroxysteroid dehydrogenase
- 11-hydroxylase deficiency
- 12-O-tetradecanoylphorbol 13-acetate
- 12-step program
- 131 I
- 131I uptake test
- 132 I
- 13-cis-retinoic acid
- 13C-octanoic acid
- 14 C-xylose test