deoxycorticosterone

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desoxycorticosterone

 [des-ok″sĭ-kor″tĭ-ko-stēr´ōn]
a mineralocorticoid with no glucocorticoid activity, secreted in small amounts by the human adrenal cortex. It is used with a glucocorticoid for replacement therapy in adrenocortical insufficiency and addison's disease and for treatment of salt-losing adrenogenital syndrome.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

de·ox·y·cor·ti·cos·ter·one (DOC),

(dē-oks'ē-kōr'ti-kos'tĕr-ōn),
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone, which occasionally appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Farlex Partner Medical Dictionary © Farlex 2012

deoxycorticosterone

(dē-ŏk′sē-kôr′tĭ-kŏs′tə-rōn′)
n.
A steroid hormone, C21H30O3, secreted by the adrenal cortex or produced synthetically and formerly used to treat adrenal insufficiency.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

deoxycorticosterone

Endocrinology An adrenal steroid with potent mineralocorticoid properties, and minimal glucocorticosteroid properties ↑ in Congenital adrenal hyperplasia, Cushing syndrome, primary aldosteronism, low renin HTN, adrenal CA ↓ in Adrenal insufficiency or hypoplasia
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone and possibly aldosterone, which rarely appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Compare: bioregulator
Synonym(s): 21-hydroxyprogesterone.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
Potent mineralocorticoid with no appreciable glucocorticoid activity.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Likewise, patients with ectopic disease had higher plasma concentrations of 11-deoxycortisol (P = 0.0040) and 11-deoxycorticosterone (P = 0.0019) than patients with pituitary CS, and higher (P = 0.0194) corticosterone concentrations than patients with adrenal CS.
2, A and B), as did all 15 steroids in the plasma panel, including the 3 steroids (11-deoxycortisol, 11-deoxycorticosterone, and cortisol) that provided the most consistent differences among patient groups (Fig.
Accumulation of these substrates, pregnenolone and progesterone will enhance the 21-hydroxylation and 11 [beta]-hydroxylation steps in the mineralocorticoid pathway resulting in an overproduction of 11-deoxycorticosterone and corticosterone.
In our case, biochemically there were decreased concentrations in: 17[alpha]-hydroxy progestrone, androstenedione, testosterone, estradiol, 11-deoxycortisol and cortisol; with increased concentrations in: progesterone, 11-deoxycorticosterone and corticosterone, as well as ACTH.
Corticosterone, 11-deoxycorticosterone, and aldosterone concentrations in the medium were measured with HPLC using UV detection (241 nm).
We could detect no secretion of 11-deoxycorticosterone from these slices.
Calibrator and IQC working solutions contained the following steroid concentrations: DHEAS, 2000 [micro]g/mL; cortisol, 200 [micro]g/mL; 17-hydroxypregnenolone, 160 [micro]g/mL; 17-hydroxyprogesterone, 120 [micro]g/mL; androstenedione, 80 [micro]g/mL; pregnenolone, corticosterone, 11-deoxycortisol, 21-deoxycortisol, and cortisone, each 40 [micro]g/mL; testosterone, 8 [micro]g/mL; and 11-deoxycorticosterone, 4 [micro]g/mL.
This extended time was necessary to achieve baseline separation of the targeted isobaric steroids 21-deoxycortisol, corticosterone and 11-deoxycortisol, and 11-deoxycorticosterone and 17-hydroxyprogesterone.
Simultaneous radioimmunoassay of plasma aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone.
Deficiency in the CYP21 gene prevents the conversion of 17-hydroxyprogesterone to 11-deoxycorticosterone, leading to an excessive production of androgen, which in turn affects several stages of growth and development (1).
Simultaneous radioimmunoassay of plasma aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hy droxyprogesterone, 11-deoxycortisol, cortisol and cortisone.
The Immunotech kit, which has a monoclonal antibody, was best with prednisolone (10%) and 5[alpha]-DHF (2.8%) but worst with methylprednisolone (50%), 11-deoxycortisol (S) (16%), 11-deoxycorticosterone (DOC) (27%), and triamcinolone (13%).