deoxycorticosterone

(redirected from 11-deoxycorticosterone)
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desoxycorticosterone

 [des-ok″sĭ-kor″tĭ-ko-stēr´ōn]
a mineralocorticoid with no glucocorticoid activity, secreted in small amounts by the human adrenal cortex. It is used with a glucocorticoid for replacement therapy in adrenocortical insufficiency and addison's disease and for treatment of salt-losing adrenogenital syndrome.

de·ox·y·cor·ti·cos·ter·one (DOC),

(dē-oks'ē-kōr'ti-kos'tĕr-ōn),
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone, which occasionally appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.

deoxycorticosterone

(dē-ŏk′sē-kôr′tĭ-kŏs′tə-rōn′)
n.
A steroid hormone, C21H30O3, secreted by the adrenal cortex or produced synthetically and formerly used to treat adrenal insufficiency.

deoxycorticosterone

Endocrinology An adrenal steroid with potent mineralocorticoid properties, and minimal glucocorticosteroid properties ↑ in Congenital adrenal hyperplasia, Cushing syndrome, primary aldosteronism, low renin HTN, adrenal CA ↓ in Adrenal insufficiency or hypoplasia

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone and possibly aldosterone, which rarely appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Compare: bioregulator
Synonym(s): 21-hydroxyprogesterone.

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
Potent mineralocorticoid with no appreciable glucocorticoid activity.
References in periodicals archive ?
Likewise, patients with ectopic disease had higher plasma concentrations of 11-deoxycortisol (P = 0.0040) and 11-deoxycorticosterone (P = 0.0019) than patients with pituitary CS, and higher (P = 0.0194) corticosterone concentrations than patients with adrenal CS.
2, A and B), as did all 15 steroids in the plasma panel, including the 3 steroids (11-deoxycortisol, 11-deoxycorticosterone, and cortisol) that provided the most consistent differences among patient groups (Fig.
Accumulation of these substrates, pregnenolone and progesterone will enhance the 21-hydroxylation and 11 [beta]-hydroxylation steps in the mineralocorticoid pathway resulting in an overproduction of 11-deoxycorticosterone and corticosterone.
In our case, biochemically there were decreased concentrations in: 17[alpha]-hydroxy progestrone, androstenedione, testosterone, estradiol, 11-deoxycortisol and cortisol; with increased concentrations in: progesterone, 11-deoxycorticosterone and corticosterone, as well as ACTH.
Corticosterone, 11-deoxycorticosterone, and aldosterone concentrations in the medium were measured with HPLC using UV detection (241 nm).
We could detect no secretion of 11-deoxycorticosterone from these slices.
Calibrator and IQC working solutions contained the following steroid concentrations: DHEAS, 2000 [micro]g/mL; cortisol, 200 [micro]g/mL; 17-hydroxypregnenolone, 160 [micro]g/mL; 17-hydroxyprogesterone, 120 [micro]g/mL; androstenedione, 80 [micro]g/mL; pregnenolone, corticosterone, 11-deoxycortisol, 21-deoxycortisol, and cortisone, each 40 [micro]g/mL; testosterone, 8 [micro]g/mL; and 11-deoxycorticosterone, 4 [micro]g/mL.
This extended time was necessary to achieve baseline separation of the targeted isobaric steroids 21-deoxycortisol, corticosterone and 11-deoxycortisol, and 11-deoxycorticosterone and 17-hydroxyprogesterone.
Simultaneous radioimmunoassay of plasma aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone.
Deficiency in the CYP21 gene prevents the conversion of 17-hydroxyprogesterone to 11-deoxycorticosterone, leading to an excessive production of androgen, which in turn affects several stages of growth and development (1).
Simultaneous radioimmunoassay of plasma aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hy droxyprogesterone, 11-deoxycortisol, cortisol and cortisone.
The Immunotech kit, which has a monoclonal antibody, was best with prednisolone (10%) and 5[alpha]-DHF (2.8%) but worst with methylprednisolone (50%), 11-deoxycortisol (S) (16%), 11-deoxycorticosterone (DOC) (27%), and triamcinolone (13%).