11-dehydrocorticosterone

11-dehydrocorticosterone

 [de-hi″dro-kor″tĭ-ko-stēr´ōn]
one of the least active of the glucocorticosteroids produced by the adrenal cortex; it affects water and salt metabolism.

11-de·hy·dro·cor·ti·co·ster·one

(dē'hī'drō-kōr-ti-kō-stĕr'-ōn),
A metabolite of corticosterone.

11-dehydrocorticosterone

/11-de·hy·dro·cor·ti·cos·ter·one/ (-kor″tĭ-kos´ter-ōn) a steroid produced by the adrenal cortex.

11-de·hy·dro·cor·ti·co·ster·one

(dē-hī'drō-kōr-ti-kos'tĕr-ōn)
A metabolite of corticosterone, found in the cortex of the suprarenal gland.

11-dehydrocorticosterone

one of the least active of the glucocorticosteroids produced by the adrenal cortex.
References in periodicals archive ?
Compound A through F (Compound A is 11-dehydrocorticosterone, Compound B is corticosterone or Reichstein's substance H, Compound C is 5[alpha]-pregnane-3[alpha], 11[beta], 17[alpha], 21-tetrol-20-one or Reichstein's substance C, Compound D is 5[alpha]-pregnane-3[beta], 11[beta], 17[alpha], 20[beta], 21-pentol or Reichstein's substance A, Compound E is cortisone or Reichstein's substance F, and Compound F is cortisol or Reichstein's substance M).
Ratio between the contents of 11-dehydrocorticosterone and corticosterone after acute and repeated stress: Effect of dehydroepiandrosterone sulfate.
In the placenta the fetus is protected from the high maternal glucocorticoid concentration through the activity of 11[beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2), which converts active 11[beta]-hydroxyglucocorticoids (cortisol in human, corticosterone in rodents) into inactive 11-ketoglucocorticoids (cortisone in human, 11-dehydrocorticosterone in rodents) (reviewed in Stewart and Krozowski 1999).
The enzyme 11[beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2) converts corticosterone to 11-dehydrocorticosterone in the distal convoluted tubules and cortical collecting ducts in rats, and cortisol to cortisone in humans.