PLCG1

(redirected from 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate)

PLCG1

A gene on chromosome 20q12-q13.1 that encodes a phospholipase which mediates production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and plays an important role in regulating signalling cascades. PLCG1 is activated by ligand-mediated activation of receptor-type tyrosine kinases (e.g., PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4) and plays a role in actin reorganisation and cell migration.

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