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1. A quinone derivative of naphthalene, reducible to naphthohydroquinone; 1,4-naphthoquinone derivatives have vitamin K activity (for example, menaquinone).
2. A class of compounds containing the naphthoquinone (1) structure.
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References in periodicals archive ?
Shukla, Synthesis and Biological Evaluation of Novel (L)-Alpha- Amino Acid Methyl Ester, Heteroalkyl, and Aryl Substituted 1,4-Naphthoquinone Derivatives as Antifungal and Antibacterial Agents, Bioorg.
Yadav, Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.
Berghot, New Unexpected Products during Heteroannulation of 1,4-naphthoquinone derivatives, Chem.
General procedure for preparing mono- (3a-g) and disubstituted 1,4-naphthoquinones (4a-d, 4f-g) from 2,3-dichloro-1,4-naphthoquinone (1)
These findings could be useful in the development of MNQand other related 1,4-naphthoquinones as potent anti-metastatic agents for future clinical use.
Figure 1 shows chemical structure of 2-[(4-hydroxyphenyl)amino]-1,4- naphthoquinone (Q7; 265.07 g/mol); it was synthesized by amination of 1,4-naphthoquinone with 4-hydroxyphenylamine, under aerobic conditions, using Ce[Cl.sub.3]*7[H.sub.2]O as the Lewis acid catalyst as previously reported [35].
Zhu, "Hydroxyl radical generation mechanism during the redox cycling process of 1,4-naphthoquinone," Environmental Science & Technology, vol.
Holmes, "Synthesis of some 1,4-naphthoquinones and reactions relating to their use in the study of bacterial growth inhibition," Canadian Journal of Chemistry, vol.
A computational study was performed for the prediction of ADME profile of each of the oxiranes derived from 1,4-naphthoquinones as well as meglumine antimoniate and the main results are presented in Table 1.
Pinto, and et al., "New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T.
tolerated dose (human) log mg/kg/day Oral Rat Acute Toxicity (LD50) mol/kg Oral Rat Chronic Toxicity (LOAEL) log mg/kg_bw/day Hepatotoxicity Yes/no Skin sensitisation Yes/no Table 2: Semiquantitative analysis of histological changes in tissues of mice treated with oxiranes derivate of natural 1,4-naphthoquinones and meglumine antimoniate.