calcitriol

(redirected from 1,25-dihydroxycholecalciferol)
Also found in: Dictionary, Encyclopedia.

calcitriol

 [kal´sĭ-tri´ol]
1,25-dihydroxycholecalciferol; a form of vitamin D used as a calcium regulator in the management of hypocalcemia in conditions such as rickets, osteodystrophy, hypoparathyroidism, and complications of renal dialysis; administered orally or intravenously.

cal·ci·tri·ol

(kal'si-trī'ol),
1α,25-Dihydroxycholecalciferol (thus, a 1,3,25-triol); formation of calcitriol is the second step in the biologic conversion of vitamin D3 to its active form; it is more potent than calcidiol.

calcitriol

/cal·ci·tri·ol/ (kal″sĭ-tri´ol)
2. a preparation of this compound, used in the treatment of hypocalcemia, hypophosphatemia, rickets, and osteodystrophy associated with a variety of disorders.

calcitriol

[kalsit′rē·ôl]
the active form of vitamin D, a regulator of calcium metabolism.
indication It is prescribed in the management of hypocalcemia in patients undergoing chronic renal dialysis and in patients with hypoparathyroidism.
contraindications Hypercalcemia, evidence of vitamin D toxicity, malabsorption syndrome, decreased renal function, or known sensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are renal toxicity and those associated with hypercalcemia, such as soft tissue calcification.

calcitriol

A form of vitamin D3 which promotes intestinal absorption of Ca2+, increases renal tubular reabsorption of Ca2+ and reduces Ca2+ resorption by bone.
 
Indications
Postmenopausal and corticosteroid-induced osteoporosis, hypocalcaemia, hypoparathyroidism, osteomalacia, rickets, renal osteodystrophy, chronic renal dialysis.

Adverse effects
Nausea, vomiting, constipation, anorexia, headache, thirst, sweating, polyuria—all due to hypercalcaemia.

calcitriol

A vitamin D analogue drug used in the treatment of low calcium levels resulting from kidney disease. Brand names are Calcijex, Rocatrol and Silkis.

calcitriol

a nonproprietary name for 1,25-dihydroxycholecalciferol; used as a calcium regulator in the management of hypocalcemia.
References in periodicals archive ?
Effects of phytase and 1,25-dihydroxycholecalciferol on phytate utilization and the quantitative requirement for calcium and phosphorus in young broiler chickens.
Regression coefficients of univariate and multivariate analyses of age, habitual physical activity, circulating insulin-like growth factor I (IGF-I) and free serum 1,25-dihydroxycholecalciferol (1,25[(OH).
Moreover, 1,25-dihydroxycholecalciferol was shown to significantly diminish production of TNF-[alpha], IL-6, IL-8 and CXCL10 in LPS-stimulated
5,10-12) Briefly, cholecalciferol, once ingested, is metabolized to 1,25-dihydroxycholecalciferol and 25-monohydroxycholecalciferol, with 1,25-dihydroxycholecalciferol being the more active metabolite of the two.
3]) in the liver and subsequently into its active metabolite 1,25-dihydroxycholecalciferol (1,25[(OH).
Here it is hydroxylated by another enzyme, 1-alpha-hydroxylase, to create the biologically active form of vitamin D, 1,25-dihydroxycholecalciferol or calcitriol.
Interaction with light, cholecalciferol, 1,25-dihydroxycholecalciferol, protein, and synthetic zeolite.
Associations between age, blood lead, and serum 1,25-dihydroxycholecalciferol levels in children.
Measurement of 1,25-dihydroxycholecalciferol in man by radio-immunoassay Clin Endocrinol 1976; 11: 225-34.
The physiologic roles of calcium, magnesium, and 1,25-dihydroxycholecalciferol (the active metabolite of vitamin [D.