: metabolite of vitamin D3 active on bone in anephric rats," Science, vol.
Over the past few years, identification of 1[alpha]-hydroxylase and 24[alpha]-hydroxylase , responsible for the production of 1,25-dihydroxycholecalciferol
[1,25[(OH).sub.2]D], and the vitamin D receptors in the cells for innate immunity highlighted the importance of this micronutrient in immune regulation (2).
Kulturun yedinci gununde olgunlasan noronlar uc gruba bolundu: Vitamin D uygulanan grup; yedinci gun, 24 ve 48 saat sureyle etanol icinde cozundurulen 10-8 M 1,25 dihidroksivitamin D3 (calcitriol, 1,25-dihydroxycholecalciferol
, Sigma C-9756.
The enzyme 1a-hydroxylase, which activates vitamin D to 1,25-dihydroxycholecalciferol
, is also stimulated, which results in increased Ca absorption from the intestines (Costanzo, 2006), because 1,25-dihydroxycholecalciferol
may enhance the synthesis of calcium binding proteins (Kumar, 1995) and calcium channels in the enterocyte (Bouillon et al., 2003).
There were no significant differences between groups in baseline serum calcium, phosphate, BAP, wPTH, 1,25-dihydroxycholecalciferol
, and NTx levels, or eGFR (Table 2).
Martin, "Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxycholecalciferol
in uremic patients," Journal of Clinical Investigation, vol.
Correction of enhanced Na(+)-H+ exchange of rat small intestinal brush-border membranes in streptozotocin-induced diabetes by insulin or 1,25-dihydroxycholecalciferol
. J Clin Invest 1991; 87: 1755-62.
inhibits the progression of arthritis in murine models of human arthritis," Journal of Nutrition, vol.
After isomerisation of previtamin D in the skin, 25-hydroxylation in the liver and 1[alpha]-hydroxylation in the kidney, the active form 1,25-dihydroxycholecalciferol
may exert the beneficial effects in the prevention and treatment of several diseases, namely in rickets, osteomalacia and osteoporosis.
) selectively inhibits proliferation of freshly isolated tumor-derived endothelial cells and induces apoptosis.
The outcomes studied included maternal/neonatal circulating serum vitamin D (25-OHD) levels at delivery, achieving 25-OHD of 80 nmol/L or more, and achieving 25-OHD concentration for maximal 1,25-dihydroxycholecalciferol
The active form of vitamin D in the body is called calcitriol (1,25-Dihydroxycholecalciferol