calcitriol

(redirected from 1,25-dihydroxy vitamin D)
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calcitriol

 [kal´sĭ-tri´ol]
1,25-dihydroxycholecalciferol; a form of vitamin D used as a calcium regulator in the management of hypocalcemia in conditions such as rickets, osteodystrophy, hypoparathyroidism, and complications of renal dialysis; administered orally or intravenously.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cal·ci·tri·ol

(kal'si-trī'ol),
1α,25-Dihydroxycholecalciferol (thus, a 1,3,25-triol); formation of calcitriol is the second step in the biologic conversion of vitamin D3 to its active form; it is more potent than calcidiol.
Farlex Partner Medical Dictionary © Farlex 2012

calcitriol

A form of vitamin D3 which promotes intestinal absorption of Ca2+, increases renal tubular reabsorption of Ca2+ and reduces Ca2+ resorption by bone.
 
Indications
Postmenopausal and corticosteroid-induced osteoporosis, hypocalcaemia, hypoparathyroidism, osteomalacia, rickets, renal osteodystrophy, chronic renal dialysis.

Adverse effects
Nausea, vomiting, constipation, anorexia, headache, thirst, sweating, polyuria—all due to hypercalcaemia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

calcitriol

A vitamin D analogue drug used in the treatment of low calcium levels resulting from kidney disease. Brand names are Calcijex, Rocatrol and Silkis.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The patient's initial laboratory results Test Result Normal range Serum calcium (mg/dL) 14.5 8.6-10 Serum albumin (g/dL) 3.3 3.9-5.1 Corrected serum calcium (mg/dL) 15.06 8.6-10 Ionized serum calcium (mg/dL) 6.37 4.64-5.28 24-hour urine calcium (mg/day) 10.4 0-300 Serum creatinine (mg/dL) 5.98 0.8-1.3 Parathyroid hormone (pg/mL) 11 15-65 Parathyroid hormone-related protein 3.3 14-27 (pg/mL) Phosphorus (mg/dL) 5.1 2.7-4.5 25-Hydroxy vitamin D (ng/mL) 18.7 20-40 1,25-Dihydroxy vitamin D (pg/mL) 19.6 18-72 Angiotensin-converting enzyme (U/L) 12 9-67 Antinuclear antibody Negative Antineutrophil cytoplasmic antibody Negative Serum IgG, IgA, IgM Normal HIV antigen and antibody Nonreactive CD4:CD8 ratio 7.4 1-4
Advancing age results in reduction of intestinal and bone 1,25-dihydroxy Vitamin D receptor.
The assay gauges the 1,25-Dihydroxy vitamin D deficiency, which is related to renal disease and is used in the diagnosis of disorders in the metabolism of 25 hydroxyvitamin D and phosphate.
25Hydroxyvitamin D and 1,25-dihydroxy vitamin D of D2 and D3 origin in maternal and umbilical cord serum after vitamin D2 supplementation in human pregnancy.
All had low serum 25-hydroxy vitamin D (5.0-21 ng/mL), high parathyroid hormone levels (143-454 pg / mL), and relatively high 1,25-dihydroxy vitamin D levels (93-195 pg/mL).
Once vitamin D is available, the body converts it first into 25-hydroxy vitamin D and then into 1,25-dihydroxy vitamin D (1,25-D).