calcitriol

(redirected from 1,25-dihroxyvitamin D3)
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calcitriol

 [kal´sĭ-tri´ol]
1,25-dihydroxycholecalciferol; a form of vitamin D used as a calcium regulator in the management of hypocalcemia in conditions such as rickets, osteodystrophy, hypoparathyroidism, and complications of renal dialysis; administered orally or intravenously.

cal·ci·tri·ol

(kal'si-trī'ol),
1α,25-Dihydroxycholecalciferol (thus, a 1,3,25-triol); formation of calcitriol is the second step in the biologic conversion of vitamin D3 to its active form; it is more potent than calcidiol.

calcitriol

A form of vitamin D3 which promotes intestinal absorption of Ca2+, increases renal tubular reabsorption of Ca2+ and reduces Ca2+ resorption by bone.
 
Indications
Postmenopausal and corticosteroid-induced osteoporosis, hypocalcaemia, hypoparathyroidism, osteomalacia, rickets, renal osteodystrophy, chronic renal dialysis.

Adverse effects
Nausea, vomiting, constipation, anorexia, headache, thirst, sweating, polyuria—all due to hypercalcaemia.

calcitriol

A vitamin D analogue drug used in the treatment of low calcium levels resulting from kidney disease. Brand names are Calcijex, Rocatrol and Silkis.