propylene glycol

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propylene glycol

 [pro´pĭ-lēn gli´kol]
a clear viscous liquid used as a moistening agent and solvent in pharmaceutical preparations.

pro·py·lene gly·col

a solvent for several water-insoluble drugs intended for parenteral administration; an ingredient of hydrophilic ointment; a viscous organic solvent frequently used in pharmaceutical preparations to dissolve drug substances with limited aqueous solubility; used in part for preparing injectable solutions of diazepam, phenytoin, pentobarbital, and other drugs.

prop·y·lene gly·col

(prōpi-lēn glīkol)
Solvent for several water-insoluble drugs intended for parenteral administration; used in part to prepare injectable solutions of diazepam, phenytoin, and drugs.
References in periodicals archive ?
aReaction conditions: 20Cu/g-Al2O3, 10 wt% glycerol aqueous solution; H2 pressure: 6 MPa; catalyst weight: 4 g; LHSV: 0.9 h-1 b 1,2-PD = 1,2-propanediol; 1-PO = 1-propanol; EG = ethylene glycol; EtOH=ethanol; MeOH = methanol
(2008) reported higher percentage of morphologically normal oocytes recovered after vitrification in dimethyl sulfoxide (DMSO) and 1,2-propanediol (PROH).
In experiment I oocytes were randomly divided into five groups i.e., 2 cryoprotectant agents (dimethyl sulfoxide and 1,2-propanediol) each used to vitrify immature oocytes at germinal vesicle (GV) stage or in vitro matured oocytes at metaphase II (M II) using non-vitrified oocytes as control.
Propylene glycol (1,2-propanediol) was added as a cosolvent to soy flour adhesives, replacing 50 percent of the water, as it should be more hydrophobic than glycerin, which has been previously examined (Wescott and Birkeland 2008, Brady et al.
The stock analysis buffer was prepared 1 day before use (for 150 assays) by mixing 200 mmol/L Tris acetate-4 mmol/L EDTA buffer, pH 7.75 (67.5 mL), water (27 mL), 1,2-propanediol (27.5 mL), and 2 mol/L potassium acetate (3.3 mL).
The final concentrations in the cuvette containing 1 mL of solution including the components of the ATP Monitoring Reagent were as follows: 0.2-800 [micro]mol/L urea, 16 mmol/L [Mg.sup.2+], 50 mmol/L K+, 6 mmol/L HC[O.sup.-.sub.3], 0.1 [micro]mol/L ATP, 2.5 mol/L 1,2-propanediol, 20 U/L ATP-hydrolyzing urease, 2 mmol/L EDTA, firefly luciferase, 100 mg/L n-luciferin, 4 mg/L L-luciferin, 1 g/L bovine serum albumin, 2 [micro]mol/L inorganic pyrophosphate, and 90 mmol/L Tris acetate, pH 7.75.
In a second experiment, urea calibration curves at seven diol concentrations between 0.5 and 4 mol/L for 1,2-propanediol, 1,3-propanediol, and 1,3-butanediol were performed.
Further studies with 1,2-propanediol, 1,3-propanediol, and 1,3-butanediol were performed.
The detection limits of urea in the sample, defined as 3 SD of the reagent blank based on 10 blank points obtained with four different concentrations of 1,2-propanediol in an optimized enzyme assay system, were as follows: 5 [micro]mol/L urea for 2 and 2.5 mol/L diol, 10 [micro]mol/L urea for 3 mol/L diol, and 50 [micro]mol/L urea for 3.5 mol/L diol.
The concentrations of the assay mixture, including the components of the ATP Monitoring Reagent, were are follows: 0.2-800 [micro]mol/L urea, 16 mmol/L [Mg.sup.2+], 50 mmol/L [K.sub.+], 6 mmol/L HC[O.sup.-.sub.3], 0.1 [micro]mol/L ATP, 2.5 mol/L 1,2-propanediol, 20 U/L ATP-hydrolyzing urease, 2 mmol/L EDTA, firefly luciferase, 100 mg/L D-luciferin, 4 mg/L L-luciferin, 1 g/L bovine serum albumin, 2 [micro]mol/L inorganic pyrophosphate, and 90 mmol/L Tris acetate, pH 7.75.
The assay using 2.5 mol/L 1,2-propanediol was linear up to 40 mmol/L.