Developing rigorous statistical approaches and implementing innovative computational tools play essential roles in translating the findings based on high-dimensional -omics data into accurate and informative medical decisions.
Motsinger-Reif reviewed current data integration techniques for joint-analysis of multiple -omics data and discussed future directions and challenges for applying these integrative approaches in personalized medicine.
As in the other "-omics," metabolomics data are gathered with high-throughput methods; nuclear magnetic resonance (NMR) spectroscopy and mass spectroscopy (MS) using robotic automation are the dominant analytical techniques used in the field today.
It is for these reasons and others, stresses Teresa Fan, an associate professor of chemistry at the University of Louisville, Kentucky, that scientists should view all the "-omics" sciences as complementary.
Experts agree the field is taking off" during a period of "'-omics' fatigue" that has fueled a degree of skepticism among some scientists.
At the Pacific Northwest National Laboratory in Richland, Washington, researcher Thomas Squier practices proteomics as part of the laboratory's systems biology approach, which integrates information from all of the -omics
disciplines to first determine how a cell functions and then develop predictive models.
Especially useful would be collaborative pooling of resources to standardize epidemiological instruments, microarray analyses, "-omics
" technologies, and other methods and materials for meaningful use among several laboratories.
You can call it metabolic profiling, metabonomics, or metabolomics; one speaker at a recent conference called it "biochemistry grown up." Scientists aren't settled on exactly what to call it, but this addition to the growing list of "-omics
" subspecialties is rapidly gaining acceptance as a vital link in the chain of knowledge starting at the genome and ending at the whole human body and how it is affected by its environment.
* To improve our understanding of the basic biology of brain development, as well as the site and mechanism of action of environmental chemicals that target the thyroid system, we must increase the use of "-omics
" technology (e.g., toxicogenomics), develop and use new imaging technologies, develop and use genetic models of thyroid hormone receptor defects or deficiency, and increase multidisciplinary and interdisciplinary research projects.