As a component of focal adhesions, Testin interacts with the cytoskeletal protein such as zyxin
, talin, vasodilator-stimulated phosphoprotein, Mena, extractable nucler antigen (EVL), alphall-spectrin, actin and actin-related proteins 7A.
For example, the team found that in a 3-D environment, cells possessing the protein zyxin
would move in a random way, exploring their local environment.
On the one hand, mitochondria are crucial for cell motility via their interaction, mediated by the outer membrane protein zyxin
, with the actin cytoskeleton.
For EIA, we used the physiologic VASP binding partner zyxin
as a capture molecule.
ActA and Human Zyxin
Harbour Arp2/3-independent Actin-polimerization Activity.
Ajuba is novel group 3 LIM protein along with zyxin
, paxillin, trip6 and others.
Other activities include the induction of various genes encoded for important proteins involved in cell development (such as laminin-5, MMPs, TGF beta, zyxin
, terminal deoxynucleotidyl transferase, and angiogenesis-related proteins) and activate signaling pathways that influence cell and tissue survival (such as ILK/PINCH/Akt).
, and moesin were identified as genes differentially expressed in these clusters.
Kleinman emphasized TB4's ability to up-regulate or "turn on" two genes, zyxin
and laminin-5, both of which are important for cellular adhesion and cell migration, two key biological activities necessary for successful wound healing.