zoledronate


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zoledronate

Zoledronic acid, Zometa® Osteoporosis A potent bisphosphonate used to ↓ fractures, ↓ bone pain Indications Postmenopausal osteoporosis, CA metastases to bone Adverse events Myalgia, pyrexia. See Biphosphonate, Osteoporosis.
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Bone recovery after zoledronate therapy in thalassemia-induced osteoporosis: a meta-analysis and systematic review.
We know that annual administration of intravenous zoledronate (also known as zoldedronic acid) at the 5-mg dose is an effective treatment for preventing fractures and decreasing fractures in osteoporotic, postmenopausal women by 25%-70%, depending on the skeletal site.
Similar effects were later shown by oral alendronate and intravenous zoledronate.
Of the 15 patients who developed BON in this series, only 1 was undergoing therapy with pamidronate alone, whereas the remainder were undergoing therapy with zoledronate alone, or zoledronate in combination with pamidronate or ibandronate.
Recent studies have reported bisphosphonate use, specifically zoledronate and alendronate, as a risk factor for atrial fibrillation in women.
The phase three trial compares an oral drug - ibandronate - to an intravenous drug - zoledronate - in the treatment of breast cancer patients with secondary cancer in their bones.
However, patent expiries of risedronate (Warner Chilcott/Eisai's Actonel/Atelvia, Takeda's Benet, generics), zoledronate (Novartis's Reclast/Aclasta, generics) and ibandronate (Roche/GlaxoSmithKline's Boniva/Bonviva, generics) will mean that the decline in sales of this drug class, which started following the loss of market exclusivity for alendronate (Merck's Fosamax/Teijin's Bonalon, generics), will persist through 2021 in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan.
It was followed by ibandronate, risedronate, strontium ranelate, calcitonin, zoledronate, raloxifene, parathyroid hormone (PTH) and hormone replacement therapy (HRT) in the primary osteoporosis and risedronate, ibandronate, calcitonin, strontium ranelate, zoledronate, PTH, HRT and raloxifene in the secondary osteoporosis, respectively.
In the overall Bisphosphonate, ibandronate (Bonviva/Boniva; Roche) and zoledronate (Aclasta/Zometa; Novartis) accounted healthy market share and showed an average sales growth rate of about of 20% in the past 2 years.
The two most common bisphosphonates currently used in the treatment of osteolytic metastatic lesions are zoledronate and pamidronate.
FDA-Approved Drugs for the Treatment and/or Prevention of Postmenopausal Osteoporosis Indications Drug Class Drug Name Prevention Treatment Bisphosphonates Alendronate X X Risedronate X X Ibandronate, oral X X Ibandronate, IV X Zoledronate X X Hormonal Systemic estrogen X Salmon calcitonin X Teriparatide X Selective estrogen Raloxifene X X receptor modulator (SERM) Biologics Denosumab X FDA=US Food and Drug Administration,; IV=intravenous.