zoledronate


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zoledronate

Zoledronic acid, Zometa® Osteoporosis A potent bisphosphonate used to ↓ fractures, ↓ bone pain Indications Postmenopausal osteoporosis, CA metastases to bone Adverse events Myalgia, pyrexia. See Biphosphonate, Osteoporosis.
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Acting on the finding that zoledronate treatment was associated with improved survival in patients with low-trauma hip fracture versus untreated patients, Ilaria Bellantuono and colleagues at England's University of Sheffield sought to determine whether the drug could extend the life span of human stem cells in culture and, if so, if the mechanism involved protection against DNA damage.
A single infusion of IV zoledronate led to quick symptomatic recovery and early mobilization.
Osteoporosis, denosumab more effective than zoledronate, Mar, 1
The patient was hospitalised for further management, and palliative radiotherapy (800 cGy, single fraction) was given to the involved vertebra along with monthly intravenous injections of zoledronate 4 mg.
Pamidronate (Aredia) and Zoledronate (Zometa) induced avascular necrosis of the jaws.
SAN ANTONIO -- Adjuvant zoledronate failed to improve outcomes in breast cancer patients with residual tumor following neoadjuvant chemotherapy in a large, randomized, phase III trial, Gunter von Minckwitz, Ph.
9 A previous clinical HORIZON trail with 107 patients indicated that intravenous zoledronate therapy significantly increased BMD of lumbar spine over 3 years.
The bisphosphonates alendronate and zoledronate are inhibitors of canine and human cell growth in vitro.
The efficacy of clodronate, pamidronate, and zoledronate in preventing bone lesions has been investigated in several randomised trials, while for ibandronate limited data from randomised trials are available (32).
Studies evaluating the effects of pamidronate and zoledronate on skeletal metastases of thyroid cancer have been reported Rosen et al.
Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate.
The drugs belonging to bisphosphonate group that produce the greatest incidence of osteochemonecrosis are zoledronate, pamidronate, alendronate, risendronate & ibandronate from greatest to the least.