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zileuton

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zileuton /zi·leu·ton/ (zi-loo´ton) an inhibitor of leukotriene formation, used as an antiasthmatic.
Zileuton (Zyflo)
A medication that interferes with the biosynthetic pathway that produces leukotrienes; used to help prevent asthma attacks.

zileuton,
a bronchodilator and leukotriene pathway inhibitor.
indications This drug is used to treat allergic rhinitis and asthma.
contraindications Factors that prohibit the use of this drug are hepatic disease, liver function test results three times higher than upper limits, and known hypersensitivity to zileuton.
adverse effects Adverse effects of this drug include dizziness, insomnia, fatigue, paresthesias, headache, nausea, abdominal pain, dyspepsia, diarrhea, liver function test abnormalities, hives, myalgia, and asthenia.

zileuton [zi-loo´ton]
an inhibitor of leukotriene formation, used in treatment of asthma; administered orally.

zileuton
Zyflo® Clinical medicine An inhibitor of 5-lipoxygenase, an enzyme central to leukotriene synthesis, which mediates inflammatory responses Indications Asthma. See Asthma.


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The FDA, which issued the call in mid June, said the reported neuropsychiatric events included cases of agitation, aggression, anxiety, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal ideation and behavior, and tremor in patients using montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo, Zyflo CR).
Byline: ANI London, June 8 (ANI): Researchers have found that a two-drug combination of Zileuton and Gleevec could be a potent treatment of a lethal cancer, called chronic myeloid leukemia (CML).
Two weeks later, he repeated the experiment but switched groups so that people who had received placebo got zileuton and vice versa.
 
 
 
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