zero-order kinetics

zero-order kinetics

Therapeutics The in vivo dynamics of drug elimination, which is linear with time, proportional to the concentration of the enzyme responsible for catabolism, and independent of substrate concentration. See Michaelis-Menten equation, Therapeutic drug monitoring. Cf First order kinetics.
References in periodicals archive ?
In order to determine the rate and drug transport mechanism of Clarithromycin from controlled release tablets, the dissolution profiles were fitted in various kinetic/mathematical models given as under Zero-Order Kinetics (W=K1t), First-Order Kinetics [ln (100-W)=In100-K2t], Higuchi Kinetics (W=K4 t ) Hixson Crowell Kinetics (100-W) 1/3 =1001/3-K3t), Korsmeyer's Peppas's Kinetics (Mt/M8 = K5tn).
It was observed that, in case of proposed formulations F1, F2, and F3, zero-order kinetics were predominant.
As the metabolising enzymes become saturated, metabolism switches to zero-order kinetics (where the drug is eliminated at a constant rate, regardless of concentration).
Values of b near 1 therefore indicate that the reaction approaches zero-order kinetics (Allen et al.
05 revealed that the value of b was significantly different from 1, suggesting that Cu release from the calcareous studied soils did not follow zero-order kinetics, which supports our previous finding that the zero-order equation failed to describe Cu release kinetics as judged by the low values of [R.
The ideal design should have an even drug release rate in the gastrointestinal tract by zero-order kinetics, but in most cases the final dosage form ends up demonstrating first-order kinetics.
3]-N and SP concentrations in the water column with time, and linear functions were found to best describe the zero-order kinetics governing decreases in N[H.
However, for the soils cropped further to 1994, zero-order kinetics improved the r values to 0.