In order to determine the rate and drug transport mechanism of Clarithromycin from controlled release tablets, the dissolution profiles were fitted in various kinetic/mathematical models given as under

Zero-Order Kinetics (W=K1t), First-Order Kinetics [ln (100-W)=In100-K2t], Higuchi Kinetics (W=K4 t ) Hixson Crowell Kinetics (100-W) 1/3 =1001/3-K3t), Korsmeyer's Peppas's Kinetics (Mt/M8 = K5tn).

It was observed that, in case of proposed formulations F1, F2, and F3,

zero-order kinetics were predominant.

As the metabolising enzymes become saturated, metabolism switches to

zero-order kinetics (where the drug is eliminated at a constant rate, regardless of concentration).

Zero-order kinetics First-order kinetics Polymer [k.

Values of b near 1 therefore indicate that the reaction approaches zero-order kinetics (Allen et al.

05 revealed that the value of b was significantly different from 1, suggesting that Cu release from the calcareous studied soils did not follow zero-order kinetics, which supports our previous finding that the zero-order equation failed to describe Cu release kinetics as judged by the low values of [R.

The ideal design should have an even drug release rate in the gastrointestinal tract by

zero-order kinetics, but in most cases the final dosage form ends up demonstrating first-order kinetics.

3]-N and SP concentrations in the water column with time, and linear functions were found to best describe the

zero-order kinetics governing decreases in N[H.

However, for the soils cropped further to 1994,

zero-order kinetics improved the r values to 0.