xanthine oxidase


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Related to xanthine oxidase: Xanthine DeHydrogenase, xanthine oxidase deficiency

xan·thine ox·i·dase

a flavoprotein containing molybdenum; an oxidoreductase catalyzing the reaction of xanthine, O2, and H2O to produce urate and superoxide. Also oxidizes hypoxanthine, some other purines and pterins, and aldehydes. A lower rate of oxidation is observed in patients with molybdenum cofactor deficiency.

xanthine oxidase

/xan·thine ox·i·dase/ (ok´sĭ-dās) a flavoprotein enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid, the final steps in the degradation of purines; deficiency, an autosomal recessive trait, causes xanthinuria.

xan·thine ox·i·dase

(zanthēn oksi-dās)
Flavoprotein containing molybdenum; also oxidizes hypoxanthine, some other purines and pterins, and aldehydes.

Schardinger,

Franz, Austrian scientist, 1853-1920.
Schardinger dextrins - the result of action of Bacillus macerans on starch.
Schardinger enzyme - a flavoprotein containing molybdenum. Synonym(s): xanthine oxidase
Schardinger reaction - an example of oxidation in the absence of O2 with an organic hydrogen acceptor.

xanthine

a purine compound found in most bodily tissues and fluids; it is a precursor of uric acid. Xanthine compounds such as theophylline have diuretic properties.

xanthine calculi
see xanthine urolith.
dimethyl xanthine
theobromine.
xanthine oxidase
key enzyme in the pathway for purine breakdown. Catalyzes the conversion of hypoxanthine to xanthine and then to uric acid. Generates hydrogen peroxide, which can be a generator of free radicals in biological systems through reactions with superoxide ions.
trimethyl xanthine
caffeine.
References in periodicals archive ?
Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury.
Long-term inhibition of xanthine oxidase by febuxostat does not decrease blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Serum xanthine oxidase in human liver disease, The American Journal of Gastroenterology, 96: 1194-1199.
Xanthine oxidase inhibitors are effective in under-excretors and over-producers by decreasing uric acid levels and lightening the load of uric acid to be excreted.
64 Values are given as the median (minimum-maximum) (Mann-Whitney U test) p: Plasma, e: Erythrocyte, MDA: Malondialdehyde, XO: Xanthine oxidase, SOD: Superoxide dismutase, F/M: Female/Male
13 CAT, catalase; GSH-Px, glutathione peroxidase; MDA, malondialdehyde; NO, nitric oxide; SOD, superoxide dismutase; XO, xanthine oxidase Values are mean [+ or -] SD (n=7) * P<0.
Under normal physiological conditions, xanthine oxidase acts as a dehydrogenase--that is, it removes hydrogen from xanthine or hypoxanthine and attaches it to NAD, thereby generating NADH.
Xanthine oxidase inhibitors may improve myocardial work efficiency by sensitising cardiac muscle cells to calcium ions, which are a key determinant of cardiac muscle function.
Results: Exercise-induced increases in plasma markers of purine catabolism (hypoxanthine, xanthine oxidase and serum uric acid) and circulating cytosolic proteins (myoglobin, fatty acid-binding protein, and creatine kinase) were significantly attenuated by LCLT.
Hyperlysinemia, sulfite oxidase deficiency, xanthine oxidase deficiency, and Ehlers-Danlos syndrome are other conditions in which ectopia lentis may also be seen in association with a variety of systemic abnormalities.
These include lactoperoxidase, lactoferrin and xanthine oxidase.
Xanthine oxidase activity increased dramatically after infection in both influenza-infected mouse lung cells and infected mouse serum.