xanthine oxidase


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xan·thine ox·i·dase

a flavoprotein containing molybdenum; an oxidoreductase catalyzing the reaction of xanthine, O2, and H2O to produce urate and superoxide. Also oxidizes hypoxanthine, some other purines and pterins, and aldehydes. A lower rate of oxidation is observed in patients with molybdenum cofactor deficiency.

xanthine oxidase

/xan·thine ox·i·dase/ (ok´sĭ-dās) a flavoprotein enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid, the final steps in the degradation of purines; deficiency, an autosomal recessive trait, causes xanthinuria.

xan·thine ox·i·dase

(zanthēn oksi-dās)
Flavoprotein containing molybdenum; also oxidizes hypoxanthine, some other purines and pterins, and aldehydes.

Schardinger,

Franz, Austrian scientist, 1853-1920.
Schardinger dextrins - the result of action of Bacillus macerans on starch.
Schardinger enzyme - a flavoprotein containing molybdenum. Synonym(s): xanthine oxidase
Schardinger reaction - an example of oxidation in the absence of O2 with an organic hydrogen acceptor.

xanthine

a purine compound found in most bodily tissues and fluids; it is a precursor of uric acid. Xanthine compounds such as theophylline have diuretic properties.

xanthine calculi
see xanthine urolith.
dimethyl xanthine
theobromine.
xanthine oxidase
key enzyme in the pathway for purine breakdown. Catalyzes the conversion of hypoxanthine to xanthine and then to uric acid. Generates hydrogen peroxide, which can be a generator of free radicals in biological systems through reactions with superoxide ions.
trimethyl xanthine
caffeine.
References in periodicals archive ?
A tannin-rich fruit extract appears to inhibit xanthine oxidase, an enzyme involved in uric acid synthesis.
Effect of adenosine on thiobarbituric acid reactive substance (TBARS), glutathione (GSH) content, superoxide dismutase (SOD) and catalase (CAT) activity xanthine oxidase (XO), xanthine dehydrogenase (XDH), uric acid, creatine phosphokinase (CPK), lactic dehydrogenase (LDH) and aspartate aminotransferase (AST) in blood and heart of rat groups.
Adenosine deaminase, AMP deaminase, 5'-Nucleotidase, Xanthine oxidase and Xanthine dehydrogenase Activities in Prostate Cancer Patients.
Xanthine oxidase is considered to be an important biological source of superoxide radicals.
Battelli, "Cytotoxicity of, and DNA damage by, active oxygen species produced by xanthine oxidase," FEBS Letters, vol.
Febuxostat is another xanthine oxidase inhibitor that is used to lower uric acid.
Xanthine oxidase (XO) plays a major role in catalyzing the oxidation of hypoxanthine to xanthine which finally forms uric acid (Saiful et al.
It can also decrease oxidative stress by inhibiting xanthine oxidase.
Long-term inhibition of xanthine oxidase by febuxostat does not decrease blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Our results revealed that an extract prepared from the leaves of Peumus boldus exhibited moderate inhibitory activities against pancreatic lipase (PL) and xanthine oxidase (XO) but pronounced inhibitory activities on [alpha]-glucosidase.
XO Determination: Xanthine oxidase enzyme activity was measured by spectrophotometric determination of absorbance level of uric acid formation from xanthine at a wave length of 293 nm and the results were expressed in terms of mIU/mg [11].