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angiotensin

 (ACE) [an″je-o-ten´sin]
a vasoconstrictive substance formed in the blood when renin is released from the juxtaglomerular apparatus in the kidney. The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. By its vasopressor action, it raises blood pressure and diminishes fluid loss in the kidney by restricting blood flow. Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex.
angiotensin-converting enzyme (ACE) an enzyme of the hydrolase class that catalyzes cleavage of a dipeptide from the C-terminal end of angiotensin I to form activated angiotensin II; called also peptidyl-dipeptidase A.
angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I to angiotensin II and inactivates bradykinin. ACE inhibitors, such as captopril, are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. They are also used as vasodilators in the treatment of congestive heart failure.

ACE

ACE

ACE

(1) Abciximab & Carbostent Evaluation in Acute Myocardial Infarction. A trial comparing outcomes of carbon-coated stenting of an infarct-related artery with and without abciximab.
Primary endpoint 30-day MACE (major acute coronary events)
Conclusion Abciximab + IRA stenting may be a viable reperfusion strategy in patients with acute myocardial infarction undergoing primary percutaneous revascularization.
(2) ASA & Carotid Endarterectomy. A trial comparing high- and low-dose aspirin to reduce the risk of stroke in patients undergoing carotid endarterectomy.
Primary endpoints 30-day MACE (major acute coronary events), stroke
Conclusion Low-dose (80, 325 mg) ASA patients did better

ACE

Angiotensin-converting enzyme, see there. Cf ACE inhibitors, also
1. Acute Care for Elderly.
2. Adriamycin, cyclophosphamide, etoposide.
3. Alcohol, chloroform, ether–obsolete anesthetic cocktail.
4. American College of Epidemiology.

ACE

Abbreviation for angiotensin-converting enzyme.

ACE

See ANGIOTENSIN-CONVERTING ENZYME.

ACE

angiotensin converting enzyme

ACE,

ACE

angiotensin-converting enzyme.

ACE inhibitors
a group of drugs used as vasodilators in the management of heart failure. They act to decrease circulating levels of angiotensin II and aldosterone. See captopril, enalapril, lisinopril.

ace

acepromazine.
References in periodicals archive ?
CONFIDENT Richard Hughes fancied his chances of a Newmarket four-timer and he came within an ace of achieving it.
TRANMERE extended their unbeaten run to eight last Saturday at Bristol Rovers and despite having to play half the game with 10 men came within an ace of taking all three points.
Ground improvements at Llanelian Road - including 400 new seats - are already in place and manager Gary Finley has strengthened the squad who came within an ace of promotion last season.
CAVAN showed terrific spirit to come within an ace of beating Meath last weekend having been a man down for most of the game.
They came within an ace of producing an amazing recovery against Ireland, but in the end had to settle for a share of the honours.
However back in 2002 Lovering was part of the Ayr United side that came within an ace of toppling Rangers in the CIS Cup Final.
LEON HASLAM sign-posted his World Superbike ambitions last week by clocking test track lap times within an ace of title contender James Toseland.
And the theory that Scotland's best clubs are vastly inferior to those south of the border was rubbished as Celtic won and Rangers came within an ace of following suit.
And Healy was within an ace of going to last summer's World Cup when he was called up as a late replacement for Roy Keane after the Manchester United man walked out on the eve of the competition, only to be denied a place in the squad because it was too late for Ireland to amend their squad.
London Scottish were indebted to the sure boot of Springbok fly-half Jannie De Beer to guide them past a brave Kendal side that went within an ace of upsetting the odds in a thrilling Tetley's Bitter Cup fourth round tie.
Four years ago Smith led his side to within an ace of the Champions Cup Final but since then Europe has been a tale of torment.
Lowly Halkyn seconds came within an ace of beating Division Five front-runners Conwy seconds, who were bowled out for 128, Nathan Howatson taking 5-23.