windup

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windup

Central sensitization, neuroplasticity Anesthesiology A physiologic ↑ sensitization of excitable neurons, coupled to a ↓ threshold for peripheral afferent pain terminals; windup may be mediated by excitatory amino acid neurotransmitters and neuropeptides; NMDA receptor inhibitors prevent 'windup' and may play a central role in managing chronic pain. See NMDA receptor antagonist, Preemptive analgesia. Cf Multimodality pain control.