The relative haplotype dosage (RHDO)  approach, on the other hand, allows the deduction of the fetal genotype by measuring the relative counts of single nucleotide polymorphism (SNP) alleles on haplotypes linked with the mutant allele and wild-type allele
in maternal plasma DNA (13).
The CTT sample showed wild-type allele
, while the corresponding conventional method sample demonstrated Gly12Cys (G12C) mutation.
The presented findings suggest that homozygous TIRAP S180L wild-type allele
has a protective effect, while the homozygous mutant type can pose a risk during the exposure to parasite, Plasmodium falciparum.
Each Oligomix contains two primers - forward and reverse - and the two probes, one for the wild-type allele
(normal) and one for the mutated allele.
Indeed, children with CA--homozygous carriers of the studied mutant allele polymorphic variant of gene IL-1[beta]--had the most severe (with frequent severe exacerbations, complications) course of the disease in comparison with the heterozygous carriers of the mutant polymorphic allele variant and homozygous carriers of wild-type allele
7) Within the SA SCA1 cohort, the most common wild-type allele
contained 30 CAG repeats (range of 27-36 repeats), whereas the most common pathogenic allele contained 47 repeats (range of 42-66 repeats, Fig.
m] of the mutant and the wild-type allele
using commercially available primers and hybridization probes (5).
69) among those with the wild-type allele
(n = 644).
Do you think that the recessive effect of the wild-type allele
influenced the difference seen in its rate of rebound versus the dominant allele's earlier rate of increase?
The normal wild-type allele
displays average metabolic activity, whereas some variants have enhanced or diminished activity.
These probes were designed so that during hybridization the donor probe formed a mismatch with the wild-type allele
In other experiments, we have demonstrated that each wild-type allele
of the GmFAD3C gene can contribute to the linolenic acid level by [approximately equal to]4 to 11 g [kg.