whole-cell vaccine


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Related to whole-cell vaccine: acellular vaccine

whole-cell vaccine

(hōl′sĕl′)
n.
A vaccine composed of suspensions of whole bacterial cells that have been killed.
References in periodicals archive ?
The whole-cell vaccines differed; some are not available in the United States.
But Stanley Plotkin, a pediatrician formerly at the University of Pennsylvania and inventor of the widely used rubella vaccine, recalls that the whole-cell vaccine used for these comparisons was an oddly ineffective version made by Connaught Laboratories that protected only about one-third of recipients.
Surprisingly, the whole-cell vaccine offered no better than 48 percent protection.
However, baboons that received the acellular vaccine took twice as long to clear the organism from their systems as those that had received the whole-cell vaccine.
Furthermore, data suggest that the whole-cell vaccine protects better against strains with the pertactin vaccine type than against strains with nonvaccine types (9).
A dose of DTaP may be given as the fifth dose in the series for children aged 4-6 years who have received either all four prior doses as whole-cell vaccine or three doses of whole-cell DTP plus dose of DTaP; this fifth doses should be given before the child enters kindergarten or elementary school.
7 years after receiving their last dose in the series if they received one or more doses of whole-cell vaccine compared with a mere 5.
The durability of protection with the acellular vaccine is not as good as with the whole cell vaccine, but the problem with the whole-cell vaccine was that it was quite reactive," causing local reactions and fevers, she said in an interview.
The use of whole-cell vaccines in humans could be inhibited by bacterial components that probably cause undesirable responses (13).