Blocking the action of the fat cell brake provides an innovative 'fat'-specific mechanism to increase cell metabolism and reduce the size of white fat
deposits, thereby treating a root cause of obesity and related metabolic diseases," explained senior study author Harshini Neelakantan.
The study calls it a "painless and bloodless drug delivery" to the white fat
tissue underneath the skin.
For many years our focus has been on learning to convert white fat
into beige fat, said Kajimura, who holds joint appointments in UCSFs Diabetes Center and at the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research.
Surprisingly, mRNA sequencing of white fat
tissue samples revealed a clear distinction between never-obese participants and both groups of obese individuals.
The origin of the beige adipocyte is complex; some beige adipocytes arise in epididymal white fat
from precursors that express platelet-derived growth factor receptor alpha PDGFRa, cD34, and spinocerebellar ataxia type 1 (SCA1) proteins [29-34].
The low melting point of white fat
allows deer to mobilize stored energy very quickly.
More importantly, now that thermogenic fat cells from human fat biopsies can be separated and enriched, primary cultures of these cells along with white fat
control cells from the same individual will help us uncover much-awaited information on human thermogenic fat cell regulation and function.
Normally when we eat something, we store it in white fat
," explained co-author Lily Dong.
If we manage to find ways to make stem cells develop into brown rather than white fat
cells, it may be possible to reduce the development of obesity.
This is the first known study to show that prenatal exposure to low, environmentally relevant concentrations of an obesogen led to transgenerational effects on white fat
volume, altered stem cell programming, and liver fat accumulation in multiple generations of mice.
Brown adipose tissue produces lots of heat by burning calories so, unlike white fat
which clings to our hips and expands our ageing waistlines, brown fat keeps the weight off.
In the simplest of terms, the difference is brown fat burns energy, while white fat