well-differentiated liposarcoma

well-differentiated liposarcoma

A well-circumscribed, slow-growing, low-grade malignancy of fat cells, which arises de novo (i.e., not from pre-existing lipomas) in deep soft tissue of thighs, retroperitoneum, and groin of middle-aged adults. As a general rule, the deeper the tumour, the more likely it is to recur.

Epidemiology
5000 new cases/year (US), which is 20% of all soft-tissue tumours; average age 50, slightly more common in males.

Clinical findings
Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome.
References in periodicals archive ?
The well-differentiated liposarcoma of the hypopharynx.
Retroperitoneal well-differentiated liposarcoma presenting as an incarcerated inguinal hernia.
Infiltrative lipomas, previously referred to as lipomatosis or well-differentiated liposarcoma, are locally aggressive tumors that infiltrate surrounding fibrous tissue, muscle, fascia, articular capsules, blood vessels, nerves, and bone.
Based on the above morphological and immunohistochemical characteristics, the definitive diagnostic was consistent with a well-differentiated liposarcoma (atypical lipomatous tumour).
A well-differentiated liposarcoma can be mistaken for a lipoma, a misdiagnosis that might result in an incomplete excision and/or recurrence.
Well-differentiated liposarcoma (the most common type) appears as a heterogeneous lipomatous mass with nonadipose septal and nodular areas (Figure 2).
3) Recurrences, which have been reported in about 5% of patients, are more common when the lipoma is associated with generalized lipomatosis, when the mass is not completely removed at surgery, or when the tumor is a well-differentiated liposarcoma incorrectly diagnosed as a benign lipoma.
We report the rare case of a well-differentiated liposarcoma arising in the tongue of a 55-year-old man.
The well-differentiated liposarcoma closely resembles a lipoma, with the exception of the presence of scattered lipoblasts along fibrous septa.
We describe herein an unusual malignant SFT of the pleura intermixed with well-differentiated liposarcoma.
Farshid and Weiss[1] recently reported a series of cases in which lymphedema may cause a localized extremity mass and create microscopic confusion with well-differentiated liposarcoma or fibromatosis.
16,17) This type of vascularity is not seen in well-differentiated liposarcomas, and this is an important feature for differentiation.