Changes in quality of life were determined at baseline and at the end of the treatment washout periods
by a questionnaire that asked about dysphoria, interference with activity, body image, health worry, food avoidance, social reaction, sexual function, and relationship impact.
After completing the first period, subjects entered a washout period
and were again given a manual toothbrush and a marketed sodium fluoride toothpaste and told to brush normally for the next 10 days.
The study design incorporated 4-month intervention periods without any washout period
All patients were recruited from a rheumatology clinic and had to have increased pain during the 2-week washout period
, during which they were not allowed to take any of their previous pain medications.
Treatment was then discontinued for a three-week washout period
, after which the treatment groups were reversed for another seven days--i.
Following a washout period
of no antipsychotic therapy for up to 7 days, a total of 446 patients between 18 and 60 years old were randomized to one of the following treatment arms: 3-6 mg/d cariprazine, 6-9 mg/d cariprazine, or placebo given once daily for 6 weeks followed by an additional 2 week safety follow-up period where no drug was administered.
After a 1-week washout period
on a gluten-free diet, each person was crossed over to the other treatment for an additional week.
5% or its vehicle four times daily for 8 days and then cross over to the other regimen for another 8 days following a washout period
After the first 8 weeks of treatment (or placebo), patients were asked to observe a 2-week washout period
, and they were then assigned to the alternative treatment for a further period of 8 weeks.
Future studies should be longer in duration to accumulate more evidence regarding predictors of long-term fracture incidence after bisphosphonate withdrawal and to identify an outcomes-based bisphosphonate washout period
for trials of sequential therapy.
A randomized placebo-controlled three-way crossover trial was separated by a washout period
of more than 3 days.
After a washout period
of 7 days, medication was crossed over and taken for 90 days more.