washout period

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washout period

A period in a clinical study during which subjects receive no treatment for the indication under study and the effects of a previous treatment are eliminated (or assumed to be eliminated).


to disperse or empty by flooding with water or other solvent.

medullary solute washout
a syndrome in which the relative hyperosmolarity of the renal medulla is reduced due to an excessive loss of sodium and chloride from the medullary interstitium, usually by diuresis. There is an inability to concentrate urine with polyuria and a compensatory polydipsia. Called also renal medullary washout.
washout period
in drug trials, the period allowed for all of the administered drug to be eliminated from the body.
References in periodicals archive ?
Changes in quality of life were determined at baseline and at the end of the treatment washout periods by a questionnaire that asked about dysphoria, interference with activity, body image, health worry, food avoidance, social reaction, sexual function, and relationship impact.
After completing the first period, subjects entered a washout period and were again given a manual toothbrush and a marketed sodium fluoride toothpaste and told to brush normally for the next 10 days.
The study design incorporated 4-month intervention periods without any washout period.
All patients were recruited from a rheumatology clinic and had to have increased pain during the 2-week washout period, during which they were not allowed to take any of their previous pain medications.
Treatment was then discontinued for a three-week washout period, after which the treatment groups were reversed for another seven days--i.
Following a washout period of no antipsychotic therapy for up to 7 days, a total of 446 patients between 18 and 60 years old were randomized to one of the following treatment arms: 3-6 mg/d cariprazine, 6-9 mg/d cariprazine, or placebo given once daily for 6 weeks followed by an additional 2 week safety follow-up period where no drug was administered.
After a 1-week washout period on a gluten-free diet, each person was crossed over to the other treatment for an additional week.
5% or its vehicle four times daily for 8 days and then cross over to the other regimen for another 8 days following a washout period.
After the first 8 weeks of treatment (or placebo), patients were asked to observe a 2-week washout period, and they were then assigned to the alternative treatment for a further period of 8 weeks.
Future studies should be longer in duration to accumulate more evidence regarding predictors of long-term fracture incidence after bisphosphonate withdrawal and to identify an outcomes-based bisphosphonate washout period for trials of sequential therapy.
A randomized placebo-controlled three-way crossover trial was separated by a washout period of more than 3 days.
After a washout period of 7 days, medication was crossed over and taken for 90 days more.