von Willebrand's disease


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Related to von Willebrand's disease: hemophilia, Von Willebrand factor, DDAVP

von Willebrand's disease

 [von vil´ĕ-brahnts]
a congenital bleeding disorder, inherited as an autosomal dominant trait, characterized by a prolonged bleeding time, deficiency of von Willebrand's factor, and often impairment of platelet adhesion. It is associated with epistaxis and increased bleeding after trauma or surgery, menorrhagia, and postpartum bleeding. Called also angiohemophilia and pseudohemophilia.

von Willebrand's disease

Etymology: Erick A. von Willebrand, Finnish physician, 1870-1949
an inherited disorder characterized by abnormally slow coagulation of the blood and spontaneous epistaxis and gingival bleeding caused by a deficiency of a component of factor VIII. Excessive bleeding is common after delivery, during menstruation, and after injury or surgery. Also called angiohemophilia, vascular hemophilia. See also hemophilia, thrombasthenia.

von Willebrand's disease

A rare group of hereditary bleeding disorders, similar to HAEMOPHILIA but usually less sevee, due to deficiency of a clotting factor necessary for PLATELET adhesion to blood vessel walls and as a carrier for Factor VIII. The condition is usually inherited as an autosomal dominant and, unlike haemophilia, occurs equally in both sexes. Some cases are automal recessive. The mutations, which are many, are on the short arm of chromosome 12. The von Willebrand factor (vWF) is a protein, the levels of which are raised in pregnancy. (E. A. von Willebrand, 1870–1949, Swedish physician).

von Willebrand's disease

An inherited lifelong bleeding disorder caused by an abnormal gene, similar to hemophilia. The gene defect results in a decreased blood concentration of a substance called von Willebrand's factor (vWF).
von Willebrand's disease; hereditary pseudohaemophilia; vascular haemophilia autosomal-dominant defect characterized by prolonged bleeding time, partial deficiency of clotting factor VIIIC, easy bruising, normal platelet count but platelet abnormality and dysfunction

von Willebrand's disease

a congenital hemorrhagic diathesis, inherited as an autosomal dominant trait in dogs, pigs and rabbits; abbreviated VWD. It is characterized by a prolonged bleeding time, deficiency of coagulation factor VIII and factor VIII-related antigen, and often impairment of platelet adhesion and usually associated with mild bleeding tendencies. Called also angiohemophilia, pseudohemophilia and vascular hemophilia.
References in periodicals archive ?
Laboratory assessment as a critical component of the appropriate diagnosis and subclassification of von Willebrand's disease.
The rapid differentiation of type IIb von Willebrand's disease from platelet-type (pseudo) von Willebrand's disease by the "neutral" monoclonal antibody binding assay.
13) Von Willebrand's disease was diagnosed in one of these patients, who was the only patient among 37 who experienced post-tonsillectomy hemorrhage who had an abnormal screening result.
Von Willebrand's disease was detected in 5 patients, 3 of whom had an additional functional platelet defect or factor V deficiency.
This patient's multimeric study revealed type I von Willebrand's disease, thus making her a candidate for desmopressin therapy.
This patient was placed on a regimen of oral contraceptives, which are often very effective in patients with von Willebrand's disease.
ZLB Behring is also sponsoring a unique Von Willebrand's Disease networking event intended to resemble a Texas-style tailgate party.
Treatment of blood with anti-vWf or ATA causes a decrease in vWf function, simulating von Willebrand's disease (vWd).
Shear rate-dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.
However, von Willebrand's disease is a more prevalent, though less well-known, bleeding disorder which affects both males and females.