It has been the impression of some that I had read the work of von Hansemann before I began my investigations.
David Paul von Hansemann, MD, PhD, (Figure 3) studied medicine in Berlin, Kiel, and Leipzig, Germany.
Histologically, malakoplakia is defined by sheets of ovoid histiocytes (called von Hansemann
histiocytes or Hansemann cells) with accumulation of 5- to 15-mm granular basophilic periodic acid-Schiff-positive, diastase-resistant inclusions (Figure 1) and calcified Michaelis-Gutmann bodies (1) (Figure 2), which are pathognomonic, although not necessary for diagnosis.
Malakoplakia was first described by Michaelis and Gutmann in 1902 and elaborated on in 1903 by von Hansemann
, who coined the term "malakoplakia," derived from the Greek malakos (soft) and plakos (plaque).