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volume of distribution

   Also found in: Dictionary/thesaurus, Legal, Financial, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
volume
the space occupied by a substance or a three-dimensional region; the capacity of such a region or of a container.

closing volume (CV)
the volume of gas in the lungs in excess of the residual volume at the time when small airways in the dependent portions close during maximal exhalation. See also closing volume.
volume of distribution
the calculated body space available for distribution of a drug. Abbreviated Vd.
minute volume
the volume of air expelled from the lungs per minute.
volume overload
packed-cell volume (PCV)
the volume of packed red cells in milliliters per 100 ml of centrifuged blood. See also packed cell volume.

volume of distribution
Vd Pharmacology A hypothetical volume of body fluid that would be required to dissolve the total amount of drug needed to achieve the same concentration as that found in the blood. See Apparent volume of distribution, Therapeutic drug monitoring.


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Low concentrations are characteristic of chronic leiver disease, being due to both decreaswed synthesis and an increase in the volume of distribution as a result of fluid retention and the formation of ascites.
Thyroid hormone is exten sively bound to plasma proteins, making the volume of distribution small and plasmapheresis a useful therapeutic modality.
], calculated by extrapolation of AUC0-T to infinity by adding CT/Ke to AUC0-T; clearance (CL/F), clearance corrected for body weight (CL/F/kg); volume of distribution (Vd/F) and volume of distribution corrected for body weight (Vd/F).
 
 
 
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