vitronectin


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vitronectin

 [vit″ro-nek´tin]
a multifunctional adhesive glycoprotein found in serum and various tissues. Its functions include regulation of the coagulation, fibrinolytic, and complement cascades, and it plays a role in hemostasis, wound healing, tissue remodeling, and cancer. It mediates the inflammatory and repair reactions at sites of tissue injury and promotes adhesion, spreading, and migration of cells. It has been shown to be identical to S protein, which was identified as an inhibitor of complement activation, binding the membrane attack complex and preventing its insertion into the membrane.

vit·ro·nec·tin

(vit'rō-nek'tin), [MIM*193190]
A plasma glycoprotein involved in inflammatory and repair reactions at sites of tissue damage.

vitronectin

/vit·ro·nec·tin/ (vit″ro-nek´tin) an adhesive glycoprotein whose many functions include regulation of the coagulation, fibrinolytic, and complement cascades, also playing a role in hemostasis, wound healing, tissue remodeling, and cancer, and promoting adhesion, spreading, and migration of cells. It has been shown to be identical to S protein, which was identified as a complement inhibitor acting to prevent insertion of the membrane attack complex into the membrane.

vitronectin

[vit′ro-nek′tin]
a multifunctional adhesive glycoprotein found in serum and various tissues. Its functions include regulation of the coagulation, fibrinolytic, and complement cascades, and it plays a role in hemostasis, wound healing, tissue remodeling, and cancer. It mediates the inflammatory and repair reactions at sites of tissue injury and promotes adhesion, spreading, and migration of cells. It has been shown to be identical to S protein, which was identified as an inhibitor of complement activation, binding the membrane attack complex and preventing its insertion into the membrane.

vit·ro·nec·tin

(vit'rō-nek'tin)
A plasma glycoprotein involved in inflammatory and repair reactions at sites of tissue damage.

vitronectin

an adhesive protein in plasma. Called also S-protein.
References in periodicals archive ?
VEGF receptor-2 (VEGFR-2) and a[sub]v[sz][sub]3 on the surface of vascular endothelial cells are both signal molecules in angiogenesis, which can be activated by fibronectin and vitronectin when cross-linked with FXIII.
Lawrence, "The serpin PAI-1 inhibits cell migration by blocking integrin binding to vitronectin," Nature, vol.
Keywords: Vitronectin Hepatocellular Carcinoma Proliferation Tumor Cell Migration.
This facilitates binding of aIIbb3 to fibrinogen, fibrin, von Willebrand Factor (vWF)and fibronectin vitronectin and thrombospondin and promotes platelet aggregation.
Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding.
5] platelets/[micro]l), and some traces of erythrocytes, leukocytes and serum proteins, such as fibrinogen, fibrin, fibronectin, vitronectin, and thrombospondin, also play a significant role in the healing process of the injured tendon (Sutter, 2007a; Fortier et al.
Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.
Stimulatory effect of cytokines to fibroblast causes the production of extracellular matrix proteins such as fibronectin, laminin and vitronectin (2).
Similarly, cell attachment to culture surfaces in vitro is often mediated by adhesion proteins such as fibronectin and vitronectin contained in serum-supplemented culture medium.
At least two, the V65 vitronectin fragment and C3f, can distinguish patients with OA from both healthy controls and patients with rheumatoid arthritis (RA).