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pyridoxine and related compounds (pyridoxal; pyridoxamine).
vitamin B6A widely used generic term for the water-soluble derivatives of 2-methyl pyridine, including pyridoxine, pyridoxal and pyridoxamine, which are critical to immune function, neural transmission, metabolism and red cell synthesis. Vitamin B6 is obtained in the diet in avocados, bananas, brown rice, corn, fish, meat, nuts, poultry and whole grains; pharmacologic doses may be effective for carpal tunnel syndrome, seizures in infants and in premenstrual syndrome.
Severe nerve damage, which requires months for recuperation.
megavitamin therapyThe administration of excess or 'hyper-doses' of water-soluble vitamins, either physician-guided–eg, to treat neuropathies, or self-prescribed by health-food advocates. See Decavitamin, Orthomolecular medicine, Vitamin.
Megavitamins, adverse effects
Thiamin CNS hyperresponsiveness–convulsions, Parkinson's disease–thiamin antagonizes l-dopa, sensory neuropathy–destruction of dorsal axon roots
Niacin/nicotinic acid & niacinamide/nicotinamide Exacerbation of asthma–histamine release, cardiac disease–arrhythmias, GI symptoms, eg nausea, vomiting, diarrhea, anorexia, DM–hyperglycemia, gout–↑ uric acid, liver disease–enzyme leakage, hepatocellular injury, portal fibrosis or massive necrosis, cholestatic jaundice, peptic ulcer disease–histamine release, ↑ acidity, skin disease
Vitamin B6 Paresthesia, headaches, asthenia, irritability
Vitamin C ↑ Iron absorption, possibly iron overload, evoking diarrhea, renal calculus formation and possibly inhibiting the bacteriolytic activity of neutrophils, G6PD deficiency–↑ red cell lysis, megaloblastic anemia–↓ vitamin B12 absorption, nephrolithiasis–oxaluria Diagn Clin Testing 1990; 28:27
Pyridoxine and related compounds (pyridoxal; pyridoxamine).
n a water-soluble vitamin found in nutritional and brewer's yeasts, beans, seeds, wheat germ, nuts, bananas, and avocados. Has been used to maintain cardiovascular health, to remedy deficiencies—including lower levels from taking hydralazine, isoniazid, MAOIs, penicillamine, and theophylline—and to treat morning sickness, asthma, carpal tunnel syndrome, depression, seborrheic dermatitis. Is also used to prevent kidney stones and the side effects from theophylline and photosensitivity. Megadoses may cause sensory neuropathy. Supplementation is contraindicated for those taking levodopa. Caution is advised for children and pregnant or lactating women, for whom the maximum daily dose is 100 mg. May cause neuropathy at large doses. Also called
pyridoxine hydrochloride or
pyridoxine hydrochloride or
Pyridoxine and related compounds (e.g., pyridoxal; pyridoxamine).