When they applied the LearnCoil program to databases of sequences, the researchers found evidence of coiled coils in fusion proteins associated with a wide variety of disease-causing viruses, including the influenza virus, Moloney murine leukemia virus, HIV, simian immunodeficiency virus, and visna virus.
and his collaborators, synthesized and analyzed proteins of the visna virus.
Like HIV in humans, animal viruses such as feline immunodeficiency virus (FIV) in cats, visna virus in sheep and simian immunodeficiency virus (SIV) in monkeys primarily infect cells of the immune system such as T cells and macrophages.
In animals, viral relatives of HIV with long and variable latency periods, such as visna virus in sheep, cause central nervous system damage even after the production of antibodies (NIAID, 1995).
Ovine progressive pneumonia of sheep is caused by a retrovirus--the visna virus.
However, antibodies normally produced by vaccines against the visna virus have not been effective.
The visna virus is transmitted at birth or through nursing or contact with saliva.
Visna virus ran second, with HTLV-I and BLV a distant third.
Narayan worked with Gonda, Gallo and others to show the visna virus similarity.