virus-associated hemophagocytic syndrome

virus-associated he·mo·phag·o·cyt·ic syndrome (hm-fg-stk)

n.

A syndrome that resembles malignant histiocytosis and follows infection with a herpes virus, such as Epstein-Barr virus.

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virus-associated hemophagocytic syndrome A hemophagocytotic condition seen in immunocompromised–♂:♀ ratio, 1:1 and in non-immunocompromised–♂:♀ ratio, 4:1 subjects, often in a background of DNA virus–eg, CMV, EBV, herpesviruses, and adenovirus and rubella infections; VAHS may accompany brucellosis, candidiasis, leishmaniasis, TB, salmonellosis, GVHD, hemolytic anemia Clinical Hepatosplenomegaly, lymphadenopathy, pulmonary infiltrates, pancytopenia–with a depleted BM, skin rash DiffDx Lymphoma, malignant histiocytosis, sinus histiocytosis with massive lymphadenopathy, lymphomatoid granulomatosis