Through this combination of molecular, computational, and stem cell biology, Max's work has helped to unlock the viral tropism
of Zika virus, as well as the effects of tuberous sclerosis on brain formation and function.
RABV variants have different reservoirs in nature (23) and to maintain its circulation the virus has adapt to the animal species sometimes affecting viral tropism
, pathogenesis, clinical outcome of the host, establishing new host-virus relationship.
The viral tropism
is also manifested by the clinical signs like occulo-nasal discharges diarrhea oral erosive lesions marked immuno-suppression and leucopenia; while viral antigen can be found in lymphoid organs and epithelial tissues of the affected animals (Kumar et al.
Limiting analysis to the V3 loop of gp120 is less difficult but may yield less accurate results since regions outside V3 are also involved in viral tropism
Most of the chapters are dedicated to viral gene expression and function and virus interaction with human host cells, describing immune response, aspects of viral tropism
, entry, pathogenesis, and latency.
Tropism analysis showed that all the viruses isolated from RPs were CCR5 utilizing but not CXCR4 utilizing (unpublished data), indicating that viral tropism
was not the cause for the rapid disease progression in the RPs enrolled in our study.
Specific tests with special indications such as a viral tropism
assay should be used prior to beginning a CCR5-cell surface receptor antagonist drug, while Human Leukocyte Allele-B * 5702 gene testing should be done prior to starting the nucleoside reverse transcriptase inhibitor drug Abacavir.
Pre-screening patients for viral tropism
is therefore a necessary but cumbersome step in initiating this drug.
In addition, the introduction of either an R5 or an X4 antagonist might require the addition of an expensive new diagnostic test--the viral tropism
assay that currently costs over $1,000--to the standard of care.
One major research focus has been the development of a mouse model to study viral tropism
and pathogenesis, investigate the immune response to dengue virus infection, and evaluate candidate anti-viral therapeutics.
Since they are active only against R5 viruses, it is necessary to determine the viral tropism
previously to the use of CCR5 antagonists in HIV treatment.
Natural and experimental infections with PyVs result in a spectrum of tumors that have some distinctions on the basis of route of infection, cofactors, and/or viral tropism