vincristine


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Related to vincristine: cyclophosphamide, methotrexate, prednisone

vincristine

 [vin-kris´tēn]
a vinca alkaloid used as an antineoplastic agent, primarily as a component of combination chemotherapy regimens for Hodgkin's disease, acute lymphoblastic leukemia, and non-Hodgkin's lymphomas, as well as in the treatment of other neoplastic disorders including Wilms' tumor, neuroblastoma, AIDS-associated Kaposi sarcoma, and rhabdomyosarcoma. Administered intravenously as the sulfate salt.

vincristine

/vin·cris·tine/ (vin-kris´tēn) an antineoplastic vinca alkaloid; used as the sulfate salt in the treatment of various neoplasms, including Hodgkin's disease, acute lymphocytic leukemia, non-Hodgkin's lymphoma, Kaposi's sarcoma associated with AIDS, and neuroblastoma.

vincristine

(vĭn-krĭs′tēn′)
n.
An alkaloid, C46H56N4O10, originally obtained from the Madagascar periwinkle and used in its sulfate form to treat acute leukemia and a variety of other neoplasms.

MOPP

A 4-drug chemotherapy regimen for stage-III Hodgkin lymphoma.
 
Adverse effects
Sterility, nausea, vomiting, immunosuppression, increased infections, myelosuppression, myelodysplasia, ANLL.

vincristine

Oncovin® AIDS A dimeric vinca alkaloid used to treat KS, thrombocytopenia, leukemias, lymphomas, solid tumors and other CAs which, like vinblastine, interrupts the mitotic spindle, causing lysis of proliferating cells Adverse effects Reversible peripheral neuropathy, constipation. Cf Vinblastine.

vincristine

A vinca alkaloid anticancer drug used to treat LEUKAEMIA. The drug is on the WHO official list. A brand name is Oncovin.

vincristine

a vinca alkaloid; the sulfate is used as an antineoplastic usually in combination with other antineoplastic agents.
References in periodicals archive ?
Taken together, these results indicated that the sesame extract was not genotoxic in somatic and germ cells but it contains components that exert antigenotoxicity effect on vincristine induced DNA lesion in mouse.
We found a rapid rise in platelet count following Vincristine treatment which was life-saving for the infant.
Some pharmacological properties of vincristine, Arch Int.
Table 1 shows the absolute number of analysed cells and mitotic indices for MCF7 and H1299 untreated cells and cells treated with usnic acid or vincristine as averages of three experiments.
Mr Houlder said Mr Jowett, of Keyworth, Notts, was injected with the cytotoxic drug vincristine, which kills cells and is almost always fatal when injected into the spine.
But after that procedure, Dr Mulhem told his junior David Morton to give a further spinal injection of the anti-cancer drug Vincristine.
combined either low of standard-dose CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with stavudine, lamivudine, and indinavir.
Wayne Jowett, of Keyworth, Nottinghamshire, should have had the drug vincristine injected into a vein rather than his spine.
Patients taking Adriamycin (doxorubicin HC1) or vincristine are going to have severe alopecia.
He required Cytosine in his spine and Vincristine - invariably fatal if administered incorrectly - in a vein to keep his condition at bay.