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a group of cytotoxic alkaloids extracted from the Madagascar periwinkle (Catharanthus roseus G. Don or Vinca rosea L.) and used as antineoplastic agents; they are cell cycle specific for the M phase of cell division and disrupt the microtubules that form the spindle apparatus. The group includes vinblastine, vincristine, vindesine, and vinorelbine tartrate.
alkaloids such as vincristine and vinblastine (antitumor agents) extracted from the periwinkle plant.
Synonym(s): Catharanthus alkaloids
vinca alkaloidsA class of cytotoxic drugs used to treat various cancers. Examples are vindesine (Eldisine), vincristine (Oncovin) and vinblastine (Velbe).
a group of alkaloids, including vinblastine and vincristine, extracted from the periwinkle plant (Vinca rosea), which arrest cell division in metaphase by disrupting the microtubules that form the spindle apparatus; used as antineoplastic agents.