vinca alkaloids


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Related to vinca alkaloids: vinblastine, vincristine, paclitaxel, Taxanes

vinca alkaloids

 [vin´kah]
a group of cytotoxic alkaloids extracted from the Madagascar periwinkle (Catharanthus roseus G. Don or Vinca rosea L.) and used as antineoplastic agents; they are cell cycle specific for the M phase of cell division and disrupt the microtubules that form the spindle apparatus. The group includes vinblastine, vincristine, vindesine, and vinorelbine tartrate.

Vinca al·ka·loids

alkaloids such as vincristine and vinblastine (antitumor agents) extracted from the periwinkle plant.

vinca alkaloids

A class of cytotoxic drugs used to treat various cancers. Examples are vindesine (Eldisine), vincristine (Oncovin) and vinblastine (Velbe).

vinca alkaloids

a group of alkaloids, including vinblastine and vincristine, extracted from the periwinkle plant (Vinca rosea), which arrest cell division in metaphase by disrupting the microtubules that form the spindle apparatus; used as antineoplastic agents.
References in periodicals archive ?
Asima Chatterjee's work in the field of science opened the doors for millions of women to excel in the field and her research on vinca alkaloids which is now widely used in chemotherapy and helps to slow down the growth rate of cancer cells.
The rationale of targeting mitosis in cancer therapy is substantiated by the successful clinical development of tubulin-disrupting agents, such as vinca alkaloids and taxanes.
Detoxication of vinca alkaloids by human P450CYP3A4-mediated metabolism: implications for the development of drug resistance.
The chemotherapeutic agents most often associated with CIPN are platinum compounds, taxanes, vinca alkaloids, thalidomide, and bortezomib.
These results indicate that ALB 109564(a) is well tolerated at the doses tested and shows preliminary evidence of clinical activity in disease types not typically treated with approved vinca alkaloids.
P-gp is a broad-spectrum transporter, which can expel different classes of cytotoxic agents, such as Vinca alkaloids, taxanes, anthracyclines, colchicine, etc.
Vinca alkaloids are used to treat pediatric leukemia and other neoplasms today.
The vinca alkaloids are the most well known compounds of this class that are presently used in the clinics.
Bender is the author of over 60 peer-reviewed scientific articles and numerous book chapters on topics including malignant lymphoma, pancreatic cancer and the clinical pharmacology of Vinca alkaloids.