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abnormality of the small intestinal mucosa with crypt hyperplasia, resulting in flattening of the mucosa and the appearance of atrophy of villi; clinically seen in malabsorption syndromes such as sprue.
villous atrophyFlattening and disappearance of the finger-like absorptive processes of the small intestine that is a feature of COELIAC DISEASE. Villous atrophy is associated with an increased density of LYMPHOCYTES in the bowel lining (intraepithelial lymphocytes), but whether they cause it is uncertain.
1. decrease in size of a normally developed organ or tissue; wasting.
2. to undergo or cause atrophy.
atrophy of local musculature due to failure to use a part of the body, due usually to pain. Is separate from neurogenic atrophy when nerve damage causes atrophy from both disuse and denervation.
occurs with aging, particularly in Siamese cats and miniature schnauzers and poodles; may be secondary to trauma, recurrent uveitis and chronic glaucoma.
the terminal stage of chronic mastitis; palpation establishes that little mammary tissue remains and inflammatory fibrous tissue has subsided.
atrophy of the optic nerve; may occur with trauma, prolonged inflammatory diseases of the eye, and retinal degeneration.
see progressive retinal atrophy.
in cachexia there is mobilization of depot fat and lipid vacuoles are progressively reduced in size and replaced by proteinaceous fluid which converts the fat depots to gelatinous masses of serous atrophy.
a common finding in a variety of intestinal diseases of animals, including viral, bacterial and protozoal infections, parasitism, hypersensitivity reactions in the bowel and alimentary lymphosarcoma. Malabsorption and diarrhea result. An idiopathic, possibly immune-mediated, villous atrophy occurs in dogs.
pertaining to or emanating from villi.
reduction in size of the villi of the intestinal mucosa caused for example by invasion by enteric viruses such as rotavirus and coronavirus. The atrophy is the result of loss of the epithelial cells of the villus. Digestion is impaired leading to a syndrome of diarrhea and bulky feces.