The scientists assessed the effectiveness (ability to stimulate vibriocidal
antibody, an immune response that correlates with protection) of a single high-dose of live cholera vaccine CVD 103-HgR.
At the October 2015 ACIP meeting, the Work Group presented an overview of cholera epidemiology and CVD 103-HgR to ACIP At the February 2016 meeting, the Work Group presented the GRADE review that summarized the strength of evidence for each of the outcomes assessed (prevention of cholera death, life-threatening cholera diarrhea, severe cholera diarrhea, and cholera diarrhea of any severity; induction of vibriocidal
antibody response; occurrence of serious and systemic adverse events; and impact on effectiveness of co-administered vaccines and medications; (https://www.
The in vitro vibriocidal
efficacy of four types of honey exhibited different results against different sero groups of honey.
The relationship of vibriocidal
antibody titre to susceptibility to cholera in family contacts of cholera patients.
splendidus, confirming the vibriocidal
potential of ethanol extracts of PG.
Incomplete correlation of serum vibriocidal
antibody titer with protection from Vibrio cholerae infection in urban Bangladesh.
marinus produces a serine protease which suppresses the vibriocidal
activity of hemocytes in infected oysters.
Activity of Five American Plants Used to Treat Infections.
Regardless of the TC P status of the VCGs used for immunization, all animals produced serum vibriocidal
titer rises against indicated strains.
In the Phase 1 trial, a single oral dose of PXVX0200 was highly immunogenic; overall, seroconversion to vibriocidal
antibody occurred in 89% of vaccinees by day 14.
Promising data from a Shanchol immunogenicity study in cholera-endemic Kolkata, India, found that vibriocidal
antibody responses after 1 dose were equivalent to those seen after 2 doses (36); however, actual efficacy trials in populations previously unexposed to cholera are needed before 1dose of Shanchol could be considered for epidemic control in Haiti.
property of the plant was reported by Akinsinde and Olukoya (8), while Malcolm and Sofowora (14) demonstrated its antibiotic action against Gram-positive organisms, such as Sarcina lutea, Staphylococcus aureus, and Mycobacterium phlei.