vesicular stomatitis

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Related to vesicular stomatitis: Vesicular stomatitis virus

ve·sic·u·lar sto·ma·ti·tis

a vesicular disease of horses, cattle, swine, and occasionally humans caused by a Vesiculovirus (vesicular stomatitis virus) in the family Rhabdoviridae; in horses and cattle, the disease usually causes mouth vesicles, that, in cattle, cannot be differentiated clinically from those of foot-and-mouth disease.

vesicular stomatitis

An acute infectious disease of cattle, swine, and horses resembling foot-and-mouth disease, caused by any of several rhabdoviruses of the genus Vesiculovirus, thought to be transmitted by biting insects.


(sto-ma-tit'is) [ stomato- + -itis]
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STOMATITIS: As caused by herpes simplex virus
Inflammation of the mouth (including the lips, tongue, and mucous membranes). See: illustration; noma; thrush


Stomatitis may be associated with viral infections, chemical irritation, radiation therapy, mouth breathing, paralysis of nerves supplying the oral area, chemotherapy that damages or destroys the mucous membranes, adverse reactions to other medicines, or acute sun damage to the lips. The nasal and oral mucosa are esp. vulnerable to trauma from dental appliances, nasal cannula, nasotracheal tubes, or catheters administering nutrients. These areas may also be damaged during surgery when an endotracheal tube is in place.


Symptoms include oral pain, esp. when eating or drinking, bad breath, or difficulty in swallowing. Findings include oral ulcers, friability of the mucous membranes, swollen cervical lymph nodes, and sometimes fever.

Patient care

Treatment depends on the cause but is often symptomatic. The mucous membranes should be kept moist and clear of tenacious secretions. Care of the teeth and gingival tissues should be comprehensive and include flossing. The pain of stomatitis may be alleviated by systemic analgesics or application of anesthetic preparations to painful lesions. It is important for patients with dentures to clean their dentures thoroughly. Dentures should be removed from unconscious or stuporous patient. See: toothbrushing

aphthous stomatitis

Aphthous ulcer.

corrosive stomatitis

Stomatitis resulting from intentional or accidental exposure to corrosive substances.

denture stomatitis

Stomatitis on the oral mucosa covered by full or partial dentures, most commonly seen on the palate although the inflammation may also be seen overlying the mandible.

Patient care

Although most patients are asymptomatic (the finding is noticed by dental professionals during oral examination, rather than by the patient), the condition should be treated to prevent progression to more serious oral diseases. Removal of plaque from dentures (as by brushing them carefully), removal of dentures at night, and sanitizing dentures regularly (as with an overnight soak in a chlorhexidine solution) all prevent the condition from occurring. Antifungal medications are used if fungi are isolated on culture swabs.

Synonym: chronic atrophic candidiasis

diphtheritic stomatitis

Stomatitis caused by infection with Corynebacterium diphtheriae.
See: diphtheria

herpetic stomatitis

Stomatitis seen with primary infection with herpes simplex virus.

major aphthous stomatitis

Stomatitis in which large recurring or migrating painful ulcers appear within the oral cavity (on the gingiva and soft palate) and sometimes on the lips.

membranous stomatitis

Stomatitis accompanied by the formation of a false or adventitious membrane.

mercurial stomatitis

Stomatitiss seen in those exposed to elemental mercury or mercury vapors.

mycotic stomatitis


nicotine stomatitis

, stomatitis nicotina
Fissuring and the formation of hyperkeratotic papules on the palate, usually caused by habitual pipe smoking. It is a form of precancer.

simple stomatitis

Stomatitis occurring in patches on the mucous membranes.

traumatic stomatitis

Stomatitis resulting from mechanical injury as from ill-fitting dentures, sharp jagged teeth, or biting the cheek.

ulcerative stomatitis

Necrotizing ulcerative gingivitis.

vesicular stomatitis

Aphthous ulcer.

Vincent stomatitis

Necrotizing ulcerative gingivitis.


inflammation of the mucosa of the mouth. It may be caused by one of many diseases of the mouth or it may accompany another disease. Both gingivitis (inflammation of the gums) and glossitis (inflammation of the tongue) are forms of stomatitis as are palatitis (or lampas in horses) and cheilitis (inflammation of lips). The specific identification of stomatitis is an important part of a clinical examination in a food animal because of the need to identify the highly infectious vesicular diseases and bluetongue.

angular stomatitis
superficial erosions and fissuring at the angles (commissures) of the mouth.
catarrhal stomatitis
diffuse erythema of lips, tongue, cheeks; causes some discomfort and unwillingness to eat.
contagious pustular stomatitis
erosive stomatitis
erosive-ulcerative stomatitis
advanced stage of stomatitis characterized by multiple erosions and deeper ulcers; complete anorexia results.
mycotic stomatitis
see mycotic stomatitis.
necrotic stomatitis of calves
see oral necrobacillosis.
papular stomatitis
see bovine papular stomatitis.
stomatitis-pneumoenteritis complex
proliferative stomatitis
a very rare disease of cattle said to be caused by a filterable agent and recorded only in association with such conditions as chlorinated naphthalene poisoning. The lesions are papular and may also occur on the teats.
vesicular stomatitis
stomatitis characterized by vesicular lesions which soon rupture to leave denuded areas which become infected, necrotic, even ulcerative. See also vesicular stomatitis, vesicular exanthema of swine, swine vesicular disease, foot-and-mouth disease.
References in periodicals archive ?
Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses.
Population dynamics of Lutzomyia shannoni (Diptera: Psychodidae) in relation to the epizootiology of vesicular stomatitis virus on Ossabaw Island, Georgia.
a leader in the development of therapeutic and preventive vaccines against infectious diseases, announced that a phase 1 study to test the safety and immunogenicity of a recombinant vesicular stomatitis virus (rVSV)-vectored HIV vaccine initiated on October 26th and, as of December 27th, 20 volunteers have been immunized.
Emergence of mammalian cell-adapted vesicular stomatitis virus from persistent infections of insect vector cells.
Vesiculoviruses (genus Vesiculovirus), such as vesicular stomatitis virus, cause fever and vesicular diseases in animals such as cattle, horses, and pigs.
Vesicular stomatitis virus, or VSV, has long been a model system for studying and understanding the life cycle of negative-strand RNA viruses, which include viruses that cause influenza, measles and rabies.
The researchers are also studying the role of insect salivary gland proteins from biting flies in spreading another important livestock disease, vesicular stomatitis.
The funds will support proof-of-concept studies in non-human primates with proprietary, plasmid DNA (pDNA, delivered using the electroporation (EP) based TriGrid[TM]delivery system (TriGrid) developed by Ichor Medical Systems) and recombinant vesicular stomatitis virus (rVSV) vector technologies towards the development of a preventive malaria vaccine.
The VesiculoVax(TM) vaccine for both pre- and post-exposure protection against the hemorrhagic diseases caused by Ebola and Marburg viruses are based on the use of vesicular stomatitis virus (rVSV) as a vehicle.
As a control, a subset of the samples was analyzed for inhibition of cellular entry mediated by the G protein of vesicular stomatitis virus (VSV-G), an animal virus that does not circulate in Saudi Arabia, and the spike protein of the human coronavirus NL63 (NL63-S), a globally circulating coronavirus.
As recently as June of this year, a suspicious livestock disease outbreak in Arizona and New Mexico had federal and private veterinarians scurrying for confirmation that the problem at hand was not the foot-and-mouth virus, but its copycat cousin, vesicular stomatitis.
Assembled from a number of academic and biopharma sources, the patents provide Profectus with access to the enabling technologies needed to advance its recombinant Vesicular Stomatitis Virus (rVSV) vectored vaccine through commercialization.

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