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verapamil/ve·rap·a·mil/ (vĕ-rap´ah-mil) a calcium channel blocker that dilates coronary arteries and decreases myocardial oxygen demand, used as the hydrochloride salt in the treatment of angina pectoris and of hypertension and the treatment and prophylaxis of supraventricular tachyarrhythmias.
A calcium channel blocker drug, C27H38N2O4, that acts as a coronary vasodilator and is used in its hydrochloride form to treat hypertension and certain cardiac arrhythmias.
a calcium channel blocker.
indications It is prescribed for the treatment of vasospastic and exertional angina, supraventricular tachycardia, atrial fibrillation, and atrial flutter.
contraindications Severe left ventricular dysfunction, hypotension, cardiogenic shock, sick sinus syndrome, or second- or third-degree atrioventricular (AV) block prohibits its use.
adverse effects Among the more serious adverse effects are hypotension, peripheral edema, AV block, bradycardia, congestive heart failure, pulmonary edema, constipation, and dizziness.
verapamilCardiology A CCB antiarrhythmic that slows transmission of impulses across the AV node and supresses the sinus node's intrinsic rhythm Indications Tachycardial supraventricular arrhythmias–eg, paroxysmal supraventricular tachycardia, A Fib with tachyarrhythmias, atrial flutter with rapid conduction, and is the parenteral emergency drug of choice Adverse effects Constipation, slowed AV conduction and sinus node automaticity, peripheral edema; it is a standard agent for managing HTN, especially in Pts with angina; it improves pain linked to obstructive cardiomyopathy, and prevents migraines Contraindications Severe left ventricular dysfunction, hypotension, sick sinus syndrome, 2º or 3º AV block, WPW, heart failure, or in Pts with accessory bypass tracts, WPW syndrome, peripheral edema; caution in renal failure. See Calcium channel blocker, Therapeutic drug monitoring. Cf Beta blocker.
verapamilA calcium channel blocker drug used to correct irregularities in the heart beat. There is evidence that verapamil and other calcium channel blockers are anti-atherogenic and can prevent recurrent narrowing of arteries, such as the coronary arteries after these have been widened by CORONARY ANGIOPLASTY. The drug is on the WHO official list. Brand names are Cordilox, Securon, Univer and Vertab SR. Formulated with trandolapril it is marketed as Tarka.
verapamilhighly negatively inotropic calcium channel-blocking agent; reduces cardiac output, slows heart rate and reduces atrioventricular conduction; used to treat angina, hypertension and cardiac arrhythmias; not to be used in conjunction with beta-blockers; tends to cause constipation Table 1
Metolazone (Metenix 5)
|Indicated for hypertension in elderly patients|
Tend to exacerbate diabetes, gout, systemic lupus erythematosus
May cause postural hypotension
|Beta-blockers ('.…lol')||Propranolol (Inderal)|
|Should not be used by patients with asthma or bradycardia or hypotension|
Should be avoided in patients with a history of Raynaud's
May cause distal paraesthesia, impotence, dizziness and exacerbation of psoriasis
|Angiotensin-converting enzyme (ACE) inhibitors ('..…pril')||Captopril|
Lisinpril (Carace; Zestril)
|Used only with care in patients taking diuretics, or those with peripheral vascular disease, generalized atherosclerosis and kidney disease|
May cause profound hypotension, persistent cough, renal impairment, angioedema and pruritic rashes
|Angiotensin II receptor antagonists ('.…sartan')||Candesartan (Animax)|
|Used only with caution in patients with aortic or mitral valve stenosis, or renal artery disease|
Tend not to be effective in Afro-Caribbean patients with left ventricular hypertrophy
|Calcium-channel blockers ('.…dipine')||Amlodipine (Istin)|
Nisoldipine (Syscor MR)
|May cause abdominal pain, nausea, flushing, oedema, headache, dizziness, constipation and sleep disturbance|
|Alpha-blockers ('.…zosin')||Doxazosin (Cardura)|
|Should not be used in patients with urinary incontinence|
Tend to cause hypotension, dizziness, vertigo, headache, fatigue
Where antihypertensive drugs are used in combination, a rule-of-thumb guide indicates:
A + C (ACE inhibitors + calcium channel blockers)
B + D (beta-blockers + diuretics)
a calcium channel blocking agent used as a vasodilator and in the treatment of cardiac arrhythmias.