verapamil


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verapamil

 [vĕ-rap´ah-mil]
a calcium channel blocking agent used as the hydrochloride salt as a coronary vasodilator in the treatment of angina pectoris and of hypertension and the treatment and prophylaxis of supraventricular tachyarrhythmias.

verapamil

/ve·rap·a·mil/ (vĕ-rap´ah-mil) a calcium channel blocker that dilates coronary arteries and decreases myocardial oxygen demand, used as the hydrochloride salt in the treatment of angina pectoris and of hypertension and the treatment and prophylaxis of supraventricular tachyarrhythmias.

verapamil

(və-răp′ə-mĭl′)
n.
A calcium channel blocker drug, C27H38N2O4, that acts as a coronary vasodilator and is used in its hydrochloride form to treat hypertension and certain cardiac arrhythmias.

verapamil

[verap′əmil]
a calcium channel blocker.
indications It is prescribed for the treatment of vasospastic and exertional angina, supraventricular tachycardia, atrial fibrillation, and atrial flutter.
contraindications Severe left ventricular dysfunction, hypotension, cardiogenic shock, sick sinus syndrome, or second- or third-degree atrioventricular (AV) block prohibits its use.
adverse effects Among the more serious adverse effects are hypotension, peripheral edema, AV block, bradycardia, congestive heart failure, pulmonary edema, constipation, and dizziness.

verapamil

Cardiology A CCB antiarrhythmic that slows transmission of impulses across the AV node and supresses the sinus node's intrinsic rhythm Indications Tachycardial supraventricular arrhythmias–eg, paroxysmal supraventricular tachycardia, A Fib with tachyarrhythmias, atrial flutter with rapid conduction, and is the parenteral emergency drug of choice Adverse effects Constipation, slowed AV conduction and sinus node automaticity, peripheral edema; it is a standard agent for managing HTN, especially in Pts with angina; it improves pain linked to obstructive cardiomyopathy, and prevents migraines Contraindications Severe left ventricular dysfunction, hypotension, sick sinus syndrome, 2º or 3º AV block, WPW, heart failure, or in Pts with accessory bypass tracts, WPW syndrome, peripheral edema; caution in renal failure. See Calcium channel blocker, Therapeutic drug monitoring. Cf Beta blocker.

verapamil

A calcium channel blocker drug used to correct irregularities in the heart beat. There is evidence that verapamil and other calcium channel blockers are anti-atherogenic and can prevent recurrent narrowing of arteries, such as the coronary arteries after these have been widened by CORONARY ANGIOPLASTY. The drug is on the WHO official list. Brand names are Cordilox, Securon, Univer and Vertab SR. Formulated with trandolapril it is marketed as Tarka.

verapamil

highly negatively inotropic calcium channel-blocking agent; reduces cardiac output, slows heart rate and reduces atrioventricular conduction; used to treat angina, hypertension and cardiac arrhythmias; not to be used in conjunction with beta-blockers; tends to cause constipation Table 1
Table 1: Drug treatment of hypertension
Drug typeExamplesComments
Thiazide diureticsBendroflumethiazide
Chlortalidone (Hygroton)
Cyclopenthiazide (Navidrex)
Indapamide (Natrilix)
Metolazone (Metenix 5)
Xipamide (Diurexan)
Indicated for hypertension in elderly patients
Tend to exacerbate diabetes, gout, systemic lupus erythematosus
May cause postural hypotension
Beta-blockers ('.…lol')Propranolol (Inderal)
Acebutolol (Sectral)
Atenolol (Tenormin)
Bisoprolol (Cardicor)
Carvedilol (Eucardic)
Celiprolol (Celectol)
Esmolol (Brevibloc)
Labetalol (Transdate)
Metoprolol (Betaloc)
Nadolol (Corgard)
Nebivol (Nebilet)
Oxprenolol (Trasicor)
Pindolol (Visken)
Sotalol (Beta-Cardone)
Timolol (Betim)
Should not be used by patients with asthma or bradycardia or hypotension
Should be avoided in patients with a history of Raynaud's
May cause distal paraesthesia, impotence, dizziness and exacerbation of psoriasis
Angiotensin-converting enzyme (ACE) inhibitors ('..…pril')Captopril
Cilazapril (Vascace)
Enalapril (Innovace)
Fosinopril (Staril)
Imidapril (Tanatril)
Lisinpril (Carace; Zestril)
Moexipril (Perdix)
Perindopril (Coversyl)
Quinapril (Accupro)
Ramipril (Tritace)
Trandolapril (Gopten)
Used only with care in patients taking diuretics, or those with peripheral vascular disease, generalized atherosclerosis and kidney disease
May cause profound hypotension, persistent cough, renal impairment, angioedema and pruritic rashes
Angiotensin II receptor antagonists ('.…sartan')Candesartan (Animax)
Eprosartan (Teveten)
Irbesartan (Aprovel)
Losartan (Cozaar)
Olmesartan (Olmetec)
Telmisartan (Micardis)
Valsartan (Diovan)
Used only with caution in patients with aortic or mitral valve stenosis, or renal artery disease
Tend not to be effective in Afro-Caribbean patients with left ventricular hypertrophy
Calcium-channel blockers ('.…dipine')Amlodipine (Istin)
Diltiazem (Calcicard)
Felodipine (Plendil)
Isradipine (Prescal)
Lacidipine (Motens)
Lercadidipine (Zanidip)
Nicardipine (Cardene)
Nifedipine (Adalat)
Nimodipine (Nimotrop)
Nisoldipine (Syscor MR)
Verapamil (Cordilox)
May cause abdominal pain, nausea, flushing, oedema, headache, dizziness, constipation and sleep disturbance
Alpha-blockers ('.…zosin')Doxazosin (Cardura)
Indoramin (Baratol)
Prazosin (Hypovase)
Terazosin (Hytrin)
Should not be used in patients with urinary incontinence
Tend to cause hypotension, dizziness, vertigo, headache, fatigue

Where antihypertensive drugs are used in combination, a rule-of-thumb guide indicates:

A + C (ACE inhibitors + calcium channel blockers)

B + D (beta-blockers + diuretics)

verapamil

a calcium channel blocking agent used as a vasodilator and in the treatment of cardiac arrhythmias.
References in periodicals archive ?
3) The drug that contained different concentrations of P-gp inhibitor verapamil hydrochloride was used for the perfusion experiment on ileum to study the influence of verapamil hydrochloride upon drug absorption.
Comparative effect and safety of verapamil in keloid and hypertrophic scar treatment: a metaanalysis.
Verapamil is a CCB used as an antiarrhythmetic agent and it is particularly useful in the management of supraventricular tachyarrhythmias (5, 6).
Massive ingestion of modified-release verapamil with a concretion and bowel infarction.
Nonsustained VF was observed in 2 of 7 (28%) verapamil strikes compared with 4 of 16 (25%) controls.
6] cells/ml) were washed twice with PBS, suspended in RPMI medium, and treated with 2 (5 [micro]M or 10 [micro]M), verapamil, and control (1% DMSO).
9,10 Calcium channel blocker Verapamil may interfere with H+K+ ATP ase due to its high affinity for the site H+K+ATP ase system which is accessible from luminal side of the stomach.
Structural effects of verapamil on cell membranes and molecular models.
Sonucta da sodyum nitroprussid, gliseril trinitrat, nikorandil, nifedipin, diltiazem ve verapamil solusyonlarinin miyojenik tonusde sirasiyla %100, %78, %85, %78,2, %83,8, %66,4 oraninda inhibisyon olusturdugu belirlenmistir.
Patients who took verapamil also had poorer overall survival, although other efficacy outcomes were not substantially different between those who did and did not take verapamil.
Mean NT-proBNP levels at rest were 1,039 pg/mL at baseline and significantly lower during calcium channel blocker therapy: 831 pg/mL while patients were on diltiazem and 897 pg/mL on verapamil.
Complete remission of symptoms occurred with usual treatment of CH including verapamil and high flow oxygen.